Claim · model-written summary
Auxin-dependent bimodal ICR1 regulation is essential for auxin maxima and gradients.
Not reportedTaxonMaterialOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValueQualifier
Verbatim
e0“bimodal regulation of ICR1 levels by auxin is essential for regulating formation of auxin local maxima and gradients”
Title
Bimodal regulation of ICR1 levels generates self-organizing auxin distribution
Ora Hazak; Uri Obolski; Tomáš Prat; et al. Proceedings of the National Academy of Sciences 2014. doi:10.1073/pnas.1413918111
Other claims from this paper (10)
- Association ICR1 levels increase with auxin response in lateral root primordia, cotyledon tips, and provascular tissues.
- Mechanism Above critical auxin levels, ICR1 is rapidly destabilized through SCF(TIR1/AFB)-dependent signaling in the embryo hypophysis and root meristem.
- Intervention effect Ectopic ICR1 expression in the embryo hypophysis reduced auxin accumulation.
- Intervention effect Ectopic ICR1 expression in the embryo hypophysis arrested root growth.
- Observation ICR1 disappeared during root regeneration and lateral root initiation with formation of a local auxin maximum after external auxin treatments.
- Observation ICR1 disappeared transiently after gravitropic stimulation.
- Intervention effect Inhibiting auxin transport and signaling impaired ICR1 destabilization.
- Intervention effect Inhibiting proteasome function impaired ICR1 destabilization.
- Intervention effect Inhibiting protein synthesis impaired ICR1 destabilization.
- Method / resource The model simulated in vivo-like auxin distribution, rootward flux, and shootward reflux without preexisting tissue polarity.