Claim · model-written summary
The DCM extract had a minimum inhibitory concentration of 12.5 mg/mL against S. typhi.
- Taxon
- Dipsacus inermis
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Dipsacus inermise1 - Treatment
- DCM extracte2
- Interactor
- S. typhi
Salmonella enterica subsp. enterica serovar Typhie2other - Outcome
- MICse2
- Value
- 12.5 mg/mLe2
Not reportedMaterialGeneCompoundOrgan / stageSecond interactorSecond interactor roleComparatorSettingDirectionQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
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Verbatim
e1“This study evaluated dichloromethane (DCM) and methanol (MeOH) extracts of Dipsacus inermis against six bacterial strains”
e2“The DCM extract demonstrated superior activity, with ZOI values of 17.87 ± 0.23 mm (S. aureus and E. aerogenes) and 16.83 ± 0.29 mm (S. typhi), and MICs of 1.562 mg/mL (B. subtilis and E. aerogenes) and 12.5 mg/mL (S. aureus, S. typhi, E. coli, and P. aeruginosa)”
Title
Drakhshaan; Tahir Ali Chohan; Aisha Qayyum; et al. PLoS ONE 2026. doi:10.1371/journal.pone.0341424
Other claims from this paper (19)
- Intervention effect The DCM extract of Dipsacus inermis showed superior antibacterial activity compared with the MeOH extract.
- Observation The DCM extract had a zone of inhibition of 17.87 ± 0.23 mm against S. aureus.
- Observation The DCM extract had a zone of inhibition of 17.87 ± 0.23 mm against E. aerogenes.
- Observation The DCM extract had a zone of inhibition of 16.83 ± 0.29 mm against S. typhi.
- Observation The DCM extract had a minimum inhibitory concentration of 1.562 mg/mL against B. subtilis.
- Observation The DCM extract had a minimum inhibitory concentration of 1.562 mg/mL against E. aerogenes.
- Observation The DCM extract had a minimum inhibitory concentration of 12.5 mg/mL against S. aureus.
- Observation The DCM extract had a minimum inhibitory concentration of 12.5 mg/mL against E. coli.
- Observation The DCM extract had a minimum inhibitory concentration of 12.5 mg/mL against P. aeruginosa.
- Observation Compounds DI10 and DI31 emerged as potent multi-target leads in silico.
- Observation Compound DI22 showed selective activity against PBP4 in silico.
- Observation ADMET profiling indicated favorable pharmacokinetics with high intestinal absorption and minimal toxicity risks.
- Observation Molecular dynamics showed RMSD stabilizing at 1.5-2.5 Å for the protein-ligand complexes.
- Observation Molecular dynamics showed compact conformations of the protein-ligand complexes (Rg 16.3-21.6 Å).
- Observation The protein-ligand complexes had favorable binding free energies of -45 to -52 kcal/mol by MM-PBSA.
- Observation DFT and MESP analyses revealed electronic features and reactive sites critical for ligand-protein interactions.
- Observation GC-MS and HPLC identified multiple bioactive compounds, primarily terpenoids and steroids, in the extracts.
- Observation One-way ANOVA confirmed significant differences among extract concentrations, highlighting dose-dependent potency.
- Mechanism DCM-derived compounds, particularly DI10 and DI31, are primarily responsible for the observed antibacterial activity.