Claim · model-written summary
The DET2 mutation causes defects in light regulated development.
- Taxon
- Arabidopsis
Arabidopsist0 - Treatment
- A mutation of glutamate 204e0
- Gene
- DET2e0
- Outcome
- defects in light-regulated developmente0
Not reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingDirectionValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“A mutation of glutamate 204, which is absolutely required for the activity of human steroid reductase, abolishes the in vivo activity of DET2 and leads to defects in light-regulated development”
t0“Arabidopsis”
Title
A Role for Brassinosteroids in Light-Dependent Development of Arabidopsis
Jianming Li; Punita Nagpal; Veronique Vitart; et al. Science 1996. doi:10.1126/science.272.5260.398
Other claims from this paper (5)
- Observation DET2 protein shares significant sequence identity with mammalian steroid 5 alpha reductases.
- Intervention effect Mutation of glutamate 204 abolishes DET2 activity in vivo.
- Intervention effect Brassinolide application ameliorates light regulated developmental defects.
- Mechanism DET2 may encode a reductase in the brassinolide biosynthetic pathway.
- Mechanism Brassinosteroids may be a phytohormone class important for light regulated development.