Claim · model-written summary
Diosmetin inhibited L. amazonensis flagellar motility by 1.0% at 100 µM.
- Taxon
- Fridericia speciosaFridericia speciosat0
- Treatment
- compounds 1-4e5
- Interactor
- L. amazonensis
Leishmania amazonensise5other - Compound
- diosmetine2
- Outcome
- L. amazonensis flagellar motilitye5
- Direction
- inhibitede5
- Value
- 1.0%e5
Not reportedMaterialGeneOrgan / stageSecond interactorSecond interactor roleComparatorSettingQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e2“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
e5“At 100 M, compounds 1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively”
Title
ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES
Reinaldo Milani; Osvaine Alves; Camila Bertanha; et al. Química Nova 2020. doi:10.21577/0100-4042.20170628
Other claims from this paper (14)
- Intervention effect Only the EAF fraction of Fridericia speciosa showed activity against Leishmania amazonensis, at 80.4% at 50 µg/mL.
- Intervention effect LCE was active against the normal human lung fibroblast line, with IC 50 of 460.7 µg/mL.
- Intervention effect EAF was active against the normal human lung fibroblast line, with IC 50 of 381.4 µg/mL.
- Observation Alpinetin was quantified at 6.21% in LCE by HPLC-DAD.
- Observation Alpinetin was quantified at 45.32% in EAF by HPLC-DAD.
- Observation Luteolin was quantified at 1.11% in LCE by HPLC-DAD.
- Observation Luteolin was quantified at 2.00% in EAF by HPLC-DAD.
- Intervention effect Alpinetin inhibited L. amazonensis flagellar motility by 40.2% at 100 µM.
- Intervention effect Luteolin inhibited L. amazonensis flagellar motility by 26.8% at 100 µM.
- Intervention effect Apigenin inhibited L. amazonensis flagellar motility by 24.8% at 100 µM.
- Intervention effect Alpinetin toxicity to the normal cell line was above 1000 µg/mL.
- Intervention effect Luteolin toxicity to the normal cell was 353.0 µg/mL.
- Intervention effect Diosmetin toxicity to the normal cell was 766.2 µg/mL.
- Intervention effect Apigenin toxicity to the normal cell was above 1000 µg/mL.