Abstract
Fridericia speciosa (Bignoniaceae) is a liana that occurs in humid to dry vegetation in eastern and southeastern Brazil. Species belonging to the genus Fridericia are employed as medicinal plants. This study evaluates the antipromastigote and cytotoxic activities of the crude extract, fractions, and compounds isolated from F. speciosa, and an HPLC (High-Performance Liquid Chromatography) analytical method was used to quantify the bioactive flavonoids. The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated from the active EtOAc-soluble fraction (EAF) of the crude ethanol extract (LCE) obtained from F. speciosa leaves. Both LCE and EAF were active against the normal human lung fibroblast cell line GM07492A (IC 50 of 460.7 g mL -1 and 381.4 g mL -1 , respectively). Only EAF showed activity against Leishmania amazonensis (80.4% at 50 g mL -1 ). Compounds 1 and 2 were quantified by HPLC-DAD in both LCE (1: 6.21%; 2: 1.11%) and EAF (1: 45.32%; 2: 2.00%). At 100 M, compounds 1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively, while their toxicities (IC 50 ) to the normal cell were > 1000, 353.0, 766.2, and >1000 g mL -1 , respectively. Therefore, F. speciosa leaves are a prolific source of bioactive flavonoids.
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Claims 15
Claim · model-written summary
Only the EAF fraction of Fridericia speciosa showed activity against Leishmania amazonensis, at 80.4% at 50 µg/mL.
- Taxon
- Fridericia speciosaFridericia speciosat0
- Treatment
- EAFe1
- Interactor
- Leishmania amazonensis
Leishmania amazonensise1other - Outcome
- activity against Leishmania amazonensise1
- Value
- 80.4% at 50 g mL -1e1
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e1“Only EAF showed activity against Leishmania amazonensis (80.4% at 50 g mL -1)”
Claim · model-written summary
LCE was active against the normal human lung fibroblast line, with IC 50 of 460.7 µg/mL.
- Taxon
- Fridericia speciosaFridericia speciosat0
- Treatment
- LCEe3
- Outcome
- IC 50e3
- Direction
- activee3
- Value
- 460.7 g mL -1e3
Not reportedComparator
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e3“Both LCE and EAF were active against the normal human lung fibroblast cell line GM07492A (IC 50 of 460.7 g mL -1 and 381.4 g mL -1 , respectively)”
Claim · model-written summary
EAF was active against the normal human lung fibroblast line, with IC 50 of 381.4 µg/mL.
- Taxon
- Fridericia speciosaFridericia speciosat0
- Treatment
- EAFe3
- Outcome
- IC 50e3
- Direction
- activee3
- Value
- 381.4 g mL -1e3
Not reportedComparator
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e3“Both LCE and EAF were active against the normal human lung fibroblast cell line GM07492A (IC 50 of 460.7 g mL -1 and 381.4 g mL -1 , respectively)”
Claim · model-written summary
Alpinetin was quantified at 6.21% in LCE by HPLC-DAD.
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e2“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
e4“Compounds 1 and 2 were quantified by HPLC-DAD in both LCE (1: 6.21%; 2: 1.11%) and EAF (1: 45.32%; 2: 2.00%)”
Claim · model-written summary
Alpinetin was quantified at 45.32% in EAF by HPLC-DAD.
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e2“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
e4“Compounds 1 and 2 were quantified by HPLC-DAD in both LCE (1: 6.21%; 2: 1.11%) and EAF (1: 45.32%; 2: 2.00%)”
Claim · model-written summary
Luteolin was quantified at 1.11% in LCE by HPLC-DAD.
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e2“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
e4“Compounds 1 and 2 were quantified by HPLC-DAD in both LCE (1: 6.21%; 2: 1.11%) and EAF (1: 45.32%; 2: 2.00%)”
Claim · model-written summary
Luteolin was quantified at 2.00% in EAF by HPLC-DAD.
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e2“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
e4“Compounds 1 and 2 were quantified by HPLC-DAD in both LCE (1: 6.21%; 2: 1.11%) and EAF (1: 45.32%; 2: 2.00%)”
Claim · model-written summary
Alpinetin inhibited L. amazonensis flagellar motility by 40.2% at 100 µM.
- Taxon
- Fridericia speciosaFridericia speciosat0
- Treatment
- compounds 1-4e5
- Interactor
- L. amazonensisLeishmania amazonensise5other
- Compound
- alpinetine2
- Outcome
- L. amazonensis flagellar motilitye5
- Direction
- inhibitede5
- Value
- 40.2%e5
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e2“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
e5“At 100 M, compounds 1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively”
Claim · model-written summary
Luteolin inhibited L. amazonensis flagellar motility by 26.8% at 100 µM.
- Taxon
- Fridericia speciosaFridericia speciosat0
- Treatment
- compounds 1-4e5
- Interactor
- L. amazonensisLeishmania amazonensise5other
- Compound
- luteoline2
- Outcome
- L. amazonensis flagellar motilitye5
- Direction
- inhibitede5
- Value
- 26.8%e5
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e2“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
e5“At 100 M, compounds 1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively”
Claim · model-written summary
Diosmetin inhibited L. amazonensis flagellar motility by 1.0% at 100 µM.
- Taxon
- Fridericia speciosaFridericia speciosat0
- Treatment
- compounds 1-4e5
- Interactor
- L. amazonensisLeishmania amazonensise5other
- Compound
- diosmetine2
- Outcome
- L. amazonensis flagellar motilitye5
- Direction
- inhibitede5
- Value
- 1.0%e5
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e2“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
e5“At 100 M, compounds 1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively”
Claim · model-written summary
Apigenin inhibited L. amazonensis flagellar motility by 24.8% at 100 µM.
- Taxon
- Fridericia speciosaFridericia speciosat0
- Treatment
- compounds 1-4e5
- Interactor
- L. amazonensisLeishmania amazonensise5other
- Compound
- apigenine2
- Outcome
- L. amazonensis flagellar motilitye5
- Direction
- inhibitede5
- Value
- 24.8%e5
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e2“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
e5“At 100 M, compounds 1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively”
Claim · model-written summary
Alpinetin toxicity to the normal cell line was above 1000 µg/mL.
- Taxon
- Fridericia speciosaFridericia speciosat0
- Treatment
- compounds 1-4e5
- Compound
- alpinetine2
- Outcome
- toxicities (IC 50 ) to the normal celle6
- Value
- > 1000e6
Not reportedComparatorDirection
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e2“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
e5“At 100 M, compounds 1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively”
e6“while their toxicities (IC 50 ) to the normal cell were > 1000, 353.0, 766.2, and >1000 g mL -1 , respectively”
Claim · model-written summary
Luteolin toxicity to the normal cell was 353.0 µg/mL.
- Taxon
- Fridericia speciosaFridericia speciosat0
- Treatment
- compounds 1-4e5
- Compound
- luteoline2
- Outcome
- toxicities (IC 50 ) to the normal celle6
- Value
- 353.0e6
Not reportedComparatorDirection
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e2“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
e5“At 100 M, compounds 1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively”
e6“while their toxicities (IC 50 ) to the normal cell were > 1000, 353.0, 766.2, and >1000 g mL -1 , respectively”
Claim · model-written summary
Diosmetin toxicity to the normal cell was 766.2 µg/mL.
- Taxon
- Fridericia speciosaFridericia speciosat0
- Treatment
- compounds 1-4e5
- Compound
- diosmetine2
- Outcome
- toxicities (IC 50 ) to the normal celle6
- Value
- 766.2e6
Not reportedComparatorDirection
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e2“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
e5“At 100 M, compounds 1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively”
e6“while their toxicities (IC 50 ) to the normal cell were > 1000, 353.0, 766.2, and >1000 g mL -1 , respectively”
Claim · model-written summary
Apigenin toxicity to the normal cell was above 1000 µg/mL.
- Taxon
- Fridericia speciosaFridericia speciosat0
- Treatment
- compounds 1-4e5
- Compound
- apigenine2
- Outcome
- toxicities (IC 50 ) to the normal celle6
- Value
- >1000e6
Not reportedComparatorDirection
Verbatim
t0“ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES”
e2“The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated”
e5“At 100 M, compounds 1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively”
e6“while their toxicities (IC 50 ) to the normal cell were > 1000, 353.0, 766.2, and >1000 g mL -1 , respectively”