Calealactone C showed low cytotoxicity for J774 macrophages, with CC50 of 31.73.

Claim · model-written summary

Calealactone C showed low cytotoxicity for J774 macrophages, with CC50 of 31.73.

Taxon

C. pinnatifidaCalea pinnatifidae0

Compound

calealactone Ce3

Outcome

cytotoxicity for J774 macrophagese3

Value

31.73e3

Qualifier

lowe3

Not reportedMaterialGeneOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirection

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Verbatim

e0

“In present work, the bioactivity guided fractionation of crude ethanol extract from leaves of C. pinnatifida led to isolation of two sesquiterpene lactones: arucanolide and calealactone C, which structures were established on the basis of spectroscopic analysis”

e3

“Additionally, calealactone C presented low cytotoxicity for J774 macrophages (CC50 31.73 µg/mL), similar to positive controls and presented antiamastigote activity with EC50 of 4.24 µg/mL”