Claim · model-written summary
The higher cytotoxicity of fresh-leaf extracts was attributed, as likely, to higher cyanogenic glycoside content.
- Taxon
- Moringa oleifera
Moringa oleiferat0 - Compound
- cyanogenic glycosidee1
- Outcome
- cytotoxice1
- Qualifier
- likelye1
Not reportedMaterialGeneOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValue
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Moringa oleifera”
e1“Extracts from fresh leaves were 19–43% more cytotoxic than those from dried leaves, depending on the ecotype, likely due to higher cyanogenic glycoside content”
Title
Mario D’Ambrosio; Elisabetta Bigagli; Lorenzo Cinci; et al. Phyton 2026. doi:10.32604/phyton.2026.073250
Other claims from this paper (8)
- Intervention effect Ethanolic extracts from fresh Moringa oleifera leaves were 19-43% more cytotoxic than extracts from dried leaves, depending on the ecotype.
- Observation Extracts of the India and Paraguay Moringa ecotypes were characterised by high levels of quercetin derivatives and caffeic acids.
- Intervention effect Extracts from the India and Paraguay ecotypes (and the Just Moringa powder) significantly inhibited LPS-induced nitric oxide production in macrophages (p < 0.05).
- Intervention effect Just Moringa and Paraguay extracts reduced iNOS gene expression (p < 0.05 and p < 0.01, respectively).
- Intervention effect Only the Paraguay extract decreased iNOS protein levels (p < 0.05).
- Intervention effect Quercetin-3-O-glucoside and rutin showed significant effects only at concentrations approximately 100-fold higher than those present in the extracts.
- Association The authors conclude that ecotypic variation strongly affects the polyphenolic composition and anti-inflammatory properties of MO leaves.
- Recommendation The authors recommend reporting both the origin and the phytochemical composition in MO-based products.