Intervention effectmodel-written summary

GhERF49 silencing enhanced cotton resistance to Verticillium wilt.

A claim from ERF49 Gene Negatively Regulates Plant Resistance to Verticillium Wilt Through Modulation of Genes Involved in Lignin Biosynthesis · 2026

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

GhERF49 silencing enhanced cotton resistance to Verticillium wilt.

Treatment
GhERF49 silencinge0
Interactor
VerticilliumVerticilliume0pathogen
Gene
GhERF49e0
Outcome
resistancee0
Direction
enhancede0

Not reportedMaterialCompoundOrgan / stageSecond interactorSecond interactor roleComparatorSettingValueQualifier

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Gossypium hirsutum
Gossypium hirsutum · TaxonChriKo · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

e0

“GhERF49 silencing enhanced cotton resistance to Verticillium wilt”

✓ located verbatim in the source · abstract, characters 782–847

Title

ERF49 Gene Negatively Regulates Plant Resistance to Verticillium Wilt Through Modulation of Genes Involved in Lignin Biosynthesis

Mingrui Li; Hang Ruan; Qi Mi; et al. International Journal of Molecular Sciences 2026. doi:10.3390/ijms27083447

Other claims from this paper (3)

Record rev-e23b619998ebbd95ae88c859b1a03ccf7a5100d499310b3e61dc7bd165d6c61f · schema claims-v0.9 · position 2 in the model’s answer

loss of function · Verticillium · Gossypium hirsutum (cotton)Positive and negative results

15 papers: 7 positive, 8 negative or no effect

6 papers in the same direction as this claim · 8 in the opposite direction

  1. negative
    Silencing GbNAC1 reduced cotton resistance to Verticillium wilt.

    Characterization, Expression, and Functional Analysis of a Novel NAC Gene Associated with Resistance to Verticillium Wilt and Abiotic Stress in Cotton · 2016

    Opposite direction

  2. negative
    Silencing GhGPA increased cotton susceptibility to wilt.

    The G-protein α subunit GhGPA positively regulates Gossypium hirsutum resistance to Verticillium dahliae via induction of SA and JA signaling pathways and ROS accumulation · 2020

    Opposite direction

  3. negative
    GhBGLU46 silencing increased cotton susceptibility to Verticillium wilt.

    Verticillium dahliae Elicitor VdSP8 Enhances Disease Resistance Through Increasing Lignin Biosynthesis in Cotton · 2024

    Opposite direction

  4. negative
    Silencing GHHIT4_4 weakened cotton resistance to Verticillium wilt.

    Genome-Wide and Expression Pattern Analysis of the HIT4 Gene Family Uncovers the Involvement of GHHIT4_4 in Response to Verticillium Wilt in Gossypium hirsutum · 2024

    Opposite direction

  5. negative
    Silencing GhKWL1 decreased resistance to Verticillium wilt.

    GhKWL1 Upregulates GhERF105 but Its Function Is Impaired by Binding with VdISC1, a Pathogenic Effector of Verticillium dahliae · 2021

    Opposite direction

  6. negative
    Silencing GbNOT2_3_5-3/8 increased wilt susceptibility versus controls.

    Genome-Wide Study of NOT2_3_5 Protein Subfamily in Cotton and Their Necessity in Resistance to Verticillium wilt · 2021 · compared with controls

    Opposite direction

  7. negative
    Silencing the target gene by VIGS significantly reduced resistance efficiency of disease-resistant cotton varieties against Verticillium wilt.

    Revealing the Complete Bispecific Phosphatase Genes (DUSPs) across the Genome and Investigating the Expression Patterns of GH_A11G3500 Resistance against Verticillium wilt · 2024

    Opposite direction

  8. negative
    Silencing Ghnup160 significantly reduced cotton resistance to Verticillium wilt.

    GhNUP160 mediates cotton resistance to Verticillium dahliae through salicylic acid and jasmonic acid pathways · 2026

    Opposite direction

6 papers more in this group

See all 15 papers →

Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.

Functional evidence on GhERF49

Claims that state a gain or loss of function of this gene and what it did to a trait, compared with wild type or a control.

GhERF49

Gossypium hirsutum (cotton)1 paper · 1 traitTested in one paper only

Only one paper in the store tests this gene's function in Gossypium hirsutum (cotton).

Disease resistance1 paper

  1. Restrains
    GhERF49 silencing enhanced cotton resistance to Verticillium wilt.

    ERF49 Gene Negatively Regulates Plant Resistance to Verticillium Wilt Through Modulation of Genes Involved in Lignin Biosynthesis · 2026

    loss of function → more of the traitThis claim

The program reads each claim's manipulation and the direction of the trait, and from them the gene's role (gain and more, or loss and less, means it promotes the trait). Roles are read by program from each claim's wording. Pairs of papers on the same host, gene and trait were checked claim by claim by two model readers; a pair is marked checked only when both accept it. Gene layer v0.8, 21 trait classes.