Claim · model-written summary
Binding of 14-3-3 proteins gives basal repression of the SOS pathway in the absence of salt stress.
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianae0 - Gene
- 14-3-3 proteinse7
- Outcome
- basal repression of the SOS pathwaye7
- Qualifier
- in the absence of salt stresse7
Not reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValue
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the Arabidopsis thaliana 14-3-3 proteins λ and κ interact with SOS2 and repress its kinase activity”
e7“The inhibition of SOS2 mediated by the binding of 14-3-3 proteins represents a novel mechanism that confers basal repression of the SOS pathway in the absence of salt stress”
Title
Inhibition of the Arabidopsis Salt Overly Sensitive Pathway by 14-3-3 Proteins
Huapeng Zhou; Huixin Lin; She Chen; et al. The Plant Cell 2014. doi:10.1105/tpc.113.117069
Other claims from this paper (9)
- Mechanism 14-3-3 proteins lambda and kappa interact with SOS2 and repress its kinase activity in Arabidopsis.
- Intervention effect Growth in the presence of salt decreased the interaction between SOS2 and the 14-3-3 proteins.
- Intervention effect Growth in the presence of salt led to SOS2 kinase activation in planta.
- Mechanism The SOS2 junction domain, which 14-3-3 lambda binds, is important for SOS2 kinase activity.
- Observation Ser-294 is identified as a phosphorylation site within the SOS2 junction domain by mass spectrometry.
- Intervention effect Mutation of Ser-294 to Ala or Asp does not affect SOS2 kinase activity in the absence of 14-3-3 proteins.
- Intervention effect The Ser-to-Ala mutation decreased the 14-3-3-mediated inhibition of SOS2 activity.
- Intervention effect The Ser-to-Asp exchange enhanced the 14-3-3-mediated inhibition of SOS2 activity.
- Mechanism 14-3-3 lambda and kappa are important regulators of salt tolerance in Arabidopsis.