Claim · model-written summary
Results argued against an EDS5 role in N-hydroxypipecolic acid biosynthesis and transport.
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianat0 - Gene
- EDS5e0
- Outcome
- biosynthesis of the immune signal N-hydroxypipecolic acid and associated transport processese0
Not reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“our results argue against a previously proposed role of EDS5 in the biosynthesis of the immune signal N-hydroxypipecolic acid and associated transport processes”
t0“In Arabidopsis thaliana”
Title
Nicola Scholten; Michael Hartmann; Sarah Abts; et al. Journal of Biological Chemistry 2024. doi:10.1016/j.jbc.2024.107667
Other claims from this paper (15)
- Observation Several previously unreported ICS1- and EDS5-dependent Arabidopsis metabolites were identified.
- Observation The identified metabolites included meta-substituted salicylic acid derivatives.
- Observation The identified metabolites included three benzoic acid analogs.
- Observation Salicyloyl-malate was identified as an ester conjugate.
- Mechanism Salicylic acid was a biosynthetic precursor for SA-Mal and SA-Asp.
- Mechanism Salicylic acid was not a precursor for the meta-substituted SA and BA derivatives.
- Observation Meta-substituted SA and BA derivatives accumulated moderately at later bacterial infection stages.
- Observation Arabidopsis leaves converted meta-formyl derivatives into meta-carboxy SA and BA derivatives.
- Intervention effect Applied meta-substituted derivatives and SA-Mal moderately affected immunity.
- Intervention effect Applied meta-substituted derivatives and SA-Mal moderately affected defence gene expression.
- Mechanism NON-EXPRESSOR OF PR GENES1 negatively regulated isochorismate-derived metabolites.
- Mechanism PBS3 affected SA conjugates and meta-substituted derivatives in opposite directions.
- Mechanism A PBS3-independent route to isochorismate-derived SA operated late in bacterial infection.
- Observation That route had little impact on immune-related characteristics.
- Mechanism The authors proposed an extended isochorismate scheme with another route to benzoate and salicylate derivatives.