Claim · model-written summary
The extracts showed antiproliferative activity against Caco-2 and MCF-7 tumor cells at GI50 25 μg/mL.
- Taxon
- Humulus lupulus
Humulus lupulust0 - Outcome
- antiproliferative activitye0
- Value
- GI50 25 μg/mLe0
- Qualifier
- tumor cell lines Caco-2 and MCF-7e0
Not reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Selective antiproliferative activity was observed against tumor cell lines Caco-2 and MCF-7 (GI50 25 μg/mL)”
t0“Hop (Humulus lupulus) Cone Residue”
Title
Giulia Boito Reyes; Emylaine Pereira dos Santos; Everton da Silva Santos; et al. Plants 2026. doi:10.3390/plants15070994
Other claims from this paper (11)
- Observation Microwave-assisted extraction identified 32 compounds in hop cone residues.
- Observation Ultrasound-assisted extraction identified 30 compounds in hop cone residues.
- Observation Identified compounds included terpenes, sesquiterpenes, oxygenated sesquiterpenes and fatty acids.
- Observation Both extracts had strong antioxidant activity, particularly the microwave extract.
- Observation The extracts had antibacterial activity against Enterobacter cloacae, Pseudomonas aeruginosa and Staphylococcus aureus at MIC 1–10 mg/mL.
- Observation The extracts inhibited Aspergillus brasiliensis at MIC 2–2.5 mg/mL.
- Observation The extracts were not cytotoxic toward Vero and PLP2 cells at GI50 above 400 μg/mL.
- Observation The microwave extract inhibited NO production with IC50 35 μg/mL.
- Observation The ultrasound extract inhibited NO production with IC50 55 μg/mL.
- Observation The microwave extract showed an SPF of 19.
- Observation The ultrasound extract showed an SPF of 18.