Claim · model-written summary
None of the tested marker compounds had a significant effect on interleukin-6 production in LPS-treated RAW 264.7 cells.
- Taxon
- Xanthii fructuse0
- Treatment
- tested marker compoundse3
- Outcome
- interleukin-6 productione3
- Direction
- no_changeinferrede3
Not reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValueQualifier
Verbatim
e0“Xanthii fructus (Compositae) is a traditional herbal medicine”
e3“None of the tested marker compounds had a significant effect on interleukin-6 production in LPS-treated RAW 264.7 cells”
Title
Soo-Jin Jeong; Sae-Rom Yoo; Chang-Seob Seo; et al. Pharmacognosy Magazine 2015. doi:10.4103/0973-1296.172966
Other claims from this paper (4)
- Method / resource A simultaneous HPLC-PDA analysis of nine phenylpropanoids in Xanthii fructus was established.
- Intervention effect Eight of the nine marker compounds significantly inhibited LPS-stimulated TNF-α production.
- Intervention effect Protocatechuic acid, caffeic acid and ferulic acid had significant inhibitory effects on LPS-induced PGE2 production in RAW 264.7 cells.
- Mechanism Each marker compound from X. fructus exerts anti-inflammatory activity by targeting different inflammation-related pathways, such as the TNF-α or PGE2 pathway.