Claim · model-written summary
Mitochondria may be a possible trigger for caspase-like proteases during PCD in the lace plant.
Not reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValue
Verbatim
e6“suggesting the mitochondria as a possible trigger for CLPs during PCD in the lace plant”
Title
Christina E. N. Lord; Adrian N. Dauphinee; Rebecca L. Watts; et al. PLoS ONE 2013. doi:10.1371/journal.pone.0057110
Other claims from this paper (7)
- Observation YVADase (caspase-1) activity was higher in the very early stages of perforation formation.
- Intervention effect Actin depolymerization with Lat B caused no change in YVADase activity.
- Intervention effect In vivo inhibition of YVADase activity prevented PCD and actin breakdown.
- Intervention effect The mitochondrial pore inhibitor CsA significantly decreased YVADase activity.
- Intervention effect The mitochondrial pore inhibitor CsA prevented PCD and actin breakdown.
- Mechanism Actin is likely a substrate for caspase-like proteases (CLPs) during PCD.
- Observation Bundling and subsequent breakdown of actin followed the YVADase activity during perforation formation.