Abstract
The rate of incorporation of carbon from C/sup 14/O/sub 2/ into the purine and pyrimidine bases of DNA and RNA after gamma irradiation of plants was investigated. It was shown that on irradiation of plants with a dose of 10,000 r a sharp decline occurred in the first 24 hr in the specific activity of DNA thymine and RNA uracil. The specific activity of cytosine was insignificantly reduced and that of the purine bases showed almost no departure from the controls. An hypothesis is advanced on the basis of the results that in the first hours after irradiation synthesis of DNA and RNA takes place, producing compounds with abnormal nucleotide ratios. The possible significance in the subsequent development of radiation injury of the appearance of these modified compounds of DNA and RNA is discussed. (auth)
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Claims 5
Claim · model-written summary
Gamma irradiation at 10,000 r sharply decreased DNA thymine specific activity within 24 hr.
- Taxon
- plantsViridiplantaee0
- Treatment
- irradiation of plants with a dose of 10,000 re0
- Outcome
- specific activity of DNA thyminee0
- Direction
- sharp declinee0
- Qualifier
- first 24 hre0
Not reportedComparator
Verbatim
e0“on irradiation of plants with a dose of 10,000 r a sharp decline occurred in the first 24 hr in the specific activity of DNA thymine and RNA uracil”
Claim · model-written summary
Gamma irradiation at 10,000 r sharply decreased RNA uracil specific activity within 24 hr.
- Taxon
- plantsViridiplantaee0
- Treatment
- irradiation of plants with a dose of 10,000 re0
- Outcome
- RNA uracile0
- Direction
- sharp declinee0
- Qualifier
- first 24 hre0
Not reportedComparator
Verbatim
e0“on irradiation of plants with a dose of 10,000 r a sharp decline occurred in the first 24 hr in the specific activity of DNA thymine and RNA uracil”
Claim · model-written summary
Cytosine specific activity was insignificantly reduced after irradiation.
- Taxon
- plantsViridiplantaee1
- Treatment
- irradiation of plants with a dose of 10,000 re1
- Outcome
- specific activity of cytosinee0
- Direction
- reducede0
Not reportedComparator
Verbatim
e0“The specific activity of cytosine was insignificantly reduced”
e1“irradiation of plants with a dose of 10,000 r”
Claim · model-written summary
Purine base specific activity showed almost no departure from controls after irradiation.
Verbatim
e0“that of the purine bases showed almost no departure from the controls”
e1“irradiation of plants with a dose of 10,000 r”
Claim · model-written summary
The authors hypothesize that early post-irradiation DNA and RNA synthesis yields abnormal nucleotide ratios.
- Taxon
- plantsViridiplantaee1
- Outcome
- compounds with abnormal nucleotide ratiose0
- Qualifier
- synthesis of DNA and RNAe0
Verbatim
e0“in the first hours after irradiation synthesis of DNA and RNA takes place, producing compounds with abnormal nucleotide ratios”
e1“irradiation of plants with a dose of 10,000 r”
The same questions in other papers
radiation · molecular: metabolites · Viridiplantae (plants)Positive and negative results
2 papers in the same direction as this paper · 2 in the opposite direction
- positive
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See all 5 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.