Paper · 1969 · Physiologia Plantarum

The Mode of Action of Maleic Hydrazide: Inhibition of Growth

Larry D. Noodén

8
claims
15
verbatim quotes
34
citations
1
research areas
✓
Open access

Abstract

Abstract Maleic hydrazide (MH) inhibits corn root elongation through an effect on cell division apparently without inhibiting cell enlargement. The decrease in the rate of elongation was apparent only after a considerable lag, over 14 hours, even with a concentration as high as 5 mM. MH (1 mM) did not inhibit His growth of roots from corn seeds given very large doses of γ‐irradiation or excised corn root segments including the elongation Zone or the cell enlargement induced by IAA in corn coleoptile sections. Many compounds including purines, pyrimidines, nucleosides. cysteine, pyridoxal, pyruvate. kinetin and CoCl 2 , many of which had previously been reported to alleviate MH inhibition in other tissues, were tested for their ability to prevent the inhibition of corn root elongation by MH, but none were effective. These data do not support the theory that MH acts by inhibiting the synthesis of or competing with some simple metabolite or hormone. Whatever its mechanism of action the failure of MH to inhibit cell enlargement in most systems indicates that it is fairly selective.

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Claims 8

Intervention effectobservedoriginal resultnegativemeasured

Claim · model-written summary

Maleic hydrazide inhibited corn root elongation.

Treatment
Maleic hydrazide (MH)e0
Outcome
corn root elongatione0
Direction
inhibitse0

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays subsp. mays
Zea mays subsp. mays · TaxonDominicus Johannes Bergsma · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“Maleic hydrazide (MH) inhibits corn root elongation through an effect on cell division apparently without inhibiting cell enlargement”

✓ located verbatim in the source · abstract, characters 9–142 · show in text ↑
Mechanismauthor interpretationoriginal resultnegativemeasured

Claim · model-written summary

Maleic hydrazide appears to inhibit corn root elongation through an effect on cell division, without inhibiting cell enlargement.

Treatment
Maleic hydrazide (MH)e0
Outcome
corn root elongatione0
Qualifier
an effect on cell divisione0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays subsp. mays
Zea mays subsp. mays · TaxonDominicus Johannes Bergsma · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“Maleic hydrazide (MH) inhibits corn root elongation through an effect on cell division apparently without inhibiting cell enlargement”

✓ located verbatim in the source · abstract, characters 9–142 · show in text ↑
Intervention effectobservedoriginal resultnegativemeasured

Claim · model-written summary

The decrease in corn root elongation by maleic hydrazide appeared only after a lag of over 14 hours, even at 5 mM.

Treatment
a concentration as high as 5 mMe1
Outcome
rate of elongatione1
Direction
decreasee1
Value
over 14 hourse1
Qualifier
only after a considerable lage1

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays subsp. mays
Zea mays subsp. mays · TaxonDominicus Johannes Bergsma · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“Maleic hydrazide (MH) inhibits corn root elongation through an effect on cell division apparently without inhibiting cell enlargement”

✓ located verbatim in the source · abstract, characters 9–142 · show in text ↑
e1

“The decrease in the rate of elongation was apparent only after a considerable lag, over 14 hours, even with a concentration as high as 5 mM”

✓ located verbatim in the source · abstract, characters 144–283 · show in text ↑
Intervention effectobservedoriginal resultno effectmeasured

Claim · model-written summary

MH at 1 mM did not inhibit growth of roots from irradiated corn seeds.

Treatment
MH (1 mM)e2
Outcome
growth of roots from corn seedse2
Direction
did not inhibite2

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays subsp. mays
Zea mays subsp. mays · TaxonDominicus Johannes Bergsma · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“Maleic hydrazide (MH) inhibits corn root elongation through an effect on cell division apparently without inhibiting cell enlargement”

✓ located verbatim in the source · abstract, characters 9–142 · show in text ↑
e2

“MH (1 mM) did not inhibit His growth of roots from corn seeds given very large doses”

✓ located verbatim in the source · abstract, characters 285–369 · show in text ↑
Intervention effectobservedoriginal resultno effectmeasured

Claim · model-written summary

MH at 1 mM did not inhibit elongation of excised corn root segments.

Organ / stage
excised corn root segmentse3
Treatment
MH (1 mM)e2
Outcome
elongatione3
Direction
did not inhibite2

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays subsp. mays
Zea mays subsp. mays · TaxonDominicus Johannes Bergsma · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e2

“MH (1 mM) did not inhibit His growth of roots from corn seeds given very large doses”

✓ located verbatim in the source · abstract, characters 285–369 · show in text ↑
e3

“or excised corn root segments including the elongation Zone”

✓ located verbatim in the source · abstract, characters 387–446 · show in text ↑
Intervention effectobservedoriginal resultno effectmeasured

Claim · model-written summary

MH at 1 mM did not inhibit the cell enlargement induced by IAA in corn coleoptile sections.

Organ / stage
corn coleoptile sectionse4
Treatment
MH (1 mM)e2
Outcome
cell enlargement induced by IAAe4
Direction
did not inhibite2

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays subsp. mays
Zea mays subsp. mays · TaxonDominicus Johannes Bergsma · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e2

“MH (1 mM) did not inhibit His growth of roots from corn seeds given very large doses”

✓ located verbatim in the source · abstract, characters 285–369 · show in text ↑
e4

“or the cell enlargement induced by IAA in corn coleoptile sections”

✓ located verbatim in the source · abstract, characters 447–513 · show in text ↑
Intervention effectobservedoriginal resultno effectmeasured

Claim · model-written summary

Purines, pyrimidines, nucleosides and other tested compounds did not prevent the inhibition of corn root elongation by MH.

Treatment
purines, pyrimidines, nucleosidese6
Outcome
the inhibition of corn root elongation by MHe5
Direction
none were effectivee5

Not reportedComparator

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays subsp. mays
Zea mays subsp. mays · TaxonDominicus Johannes Bergsma · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“Maleic hydrazide (MH) inhibits corn root elongation through an effect on cell division apparently without inhibiting cell enlargement”

✓ located verbatim in the source · abstract, characters 9–142 · show in text ↑
e5

“were tested for their ability to prevent the inhibition of corn root elongation by MH, but none were effective”

✓ located verbatim in the source · abstract, characters 715–825 · show in text ↑
e6

“Many compounds including purines, pyrimidines, nucleosides”

✓ located verbatim in the source · abstract, characters 515–573 · show in text ↑
Mechanismauthor interpretationoriginal resultnegativemeasured

Claim · model-written summary

These data do not support the theory that MH inhibits synthesis of, or competes with, a simple metabolite or hormone.

Outcome
corn root elongatione0
Qualifier
the theory that MH acts by inhibiting the synthesise7

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays subsp. mays
Zea mays subsp. mays · TaxonDominicus Johannes Bergsma · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e0

“Maleic hydrazide (MH) inhibits corn root elongation through an effect on cell division apparently without inhibiting cell enlargement”

✓ located verbatim in the source · abstract, characters 9–142 · show in text ↑
e7

“These data do not support the theory that MH acts by inhibiting the synthesis of or competing with some simple metabolite or hormone”

✓ located verbatim in the source · abstract, characters 827–959 · show in text ↑

Maleic hydrazide · molecular: metabolites · Zea mays (maize)Results agree

2 papers: 0 positive, 2 negative or no effect

1 paper in the same direction as this paper

  1. negative
See all 2 papers →

Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.