Abstract
Polyphenolic grapevine components involved in plant resistance against pathogens possess various pharmacological properties that include nitric oxide (NO)-dependent vasodilation and anti-inflammatory and free radical scavenging activities, which may explain the protective effect of moderate red wine consumption against cardiovascular disease. The aim of this work was (a) to verify the possibility that preharvest treatments of grapevine with a plant activator, benzo-(1,2,3)-thiadiazole-7-carbothioic acid S-methyl ester (BTH), could lead to an enriched nutraceutical potential of wine and (b) to characterize the profile of metabolites responsible for pharmacological activity. Plant spraying at the end of veraison, with a water suspension of BTH (0.3 mM), led to increased whole anthocyanin content as confirmed by HPLC comparative analysis. Extracts from berry skins of BTH-treated grapevines caused NO-dependent vasorelaxation, with a concentration-response curve that was significantly shifted to the left of the control non-BTH-treated curve. Moreover, 1:1000 dilutions of berry extracts from BTH-treated plants significantly increased basal production of guanosine 3',5'-cyclic monophosphate (cGMP) in human vascular endothelial cells when compared to the corresponding extracts of untreated plants. These results show that BTH treatment increases anthocyanin content of grape extracts, as well as their ability to induce NO-mediated vasoprotection. No increase of anthocyanin content was observed in the wine extracts from BTH-treated vines. It is concluded that BTH treatment could be exploited to increase the nutraceutical potential of grapes.
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Claims 5
Claim · model-written summary
BTH spraying increased whole anthocyanin content.
- Taxon
- Grapet0
- Organ / stage
- end of veraisone0
- Treatment
- BTH (0.3 mM)e0
- Outcome
- whole anthocyanin contente0
- Direction
- increasede0
Not reportedComparator
Verbatim
e0“Plant spraying at the end of veraison, with a water suspension of BTH (0.3 mM), led to increased whole anthocyanin content as confirmed by HPLC comparative analysis.”
t0“Grape”
Claim · model-written summary
Berry skin extracts from BTH-treated grapevines produced a left-shifted NO-dependent vasorelaxation response.
- Organ / stage
- berry skinse0
- Treatment
- BTH-treatede0
- Outcome
- NO-dependent vasorelaxatione0
- Direction
- shifted to the lefte0
- Comparator
- control non-BTH-treatede0
VitisOrganisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Extracts from berry skins of BTH-treated grapevines caused NO-dependent vasorelaxation, with a concentration-response curve that was significantly shifted to the left of the control non-BTH-treated curve.”
Claim · model-written summary
Berry extracts from BTH-treated plants increased basal cGMP production in human endothelial cells versus untreated-plant extracts.
Verbatim
e0“1:1000 dilutions of berry extracts from BTH-treated plants significantly increased basal production of guanosine 3',5'-cyclic monophosphate (cGMP) in human vascular endothelial cells when compared to the corresponding extracts of untreated plants.”
t0“Grape”
Claim · model-written summary
BTH did not increase anthocyanin content in wine extracts.
Not reportedComparator
Verbatim
e0“No increase of anthocyanin content was observed in the wine extracts from BTH-treated vines.”
t0“Grape”
Claim · model-written summary
The authors propose BTH treatment to increase the nutraceutical potential of grapes.
Verbatim
e0“It is concluded that BTH treatment could be exploited to increase the nutraceutical potential of grapes.”
The same questions in other papers
acibenzolar-S-methyl · quality: phytochemicals · VitisResults agree
4 papers in the same direction as this paper
- positive
- positive
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1 paper more in this group
See all 5 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.