Abstract
The plant hormone auxin regulates diverse aspects of plant growth and development. We report that in Arabidopsis, auxin response is dependent on a ubiquitin-ligase (E3) complex called SCFTIR1. The complex consists of proteins related to yeast Skp1p and Cdc53p called ASK and AtCUL1, respectively, as well as the F-box protein TIR1. Mutations in either ASK1 or TIR1 result in decreased auxin response. Further, overexpression of TIR1 promotes auxin response suggesting that SCFTIR1 is limiting for the response. These results provide new support for a model in which auxin action depends on the regulated proteolysis of repressor proteins.
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Claims 6
Claim · model-written summary
Arabidopsis auxin response depends on SCFTIR1.
- Taxon
- Arabidopsis
Arabidopsist0 - Gene
- SCFTIR1e0
- Outcome
- auxin responsee0
- Qualifier
- dependent one0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“auxin response is dependent on a ubiquitin-ligase (E3) complex called SCFTIR1”
t0“Arabidopsis thaliana”
Claim · model-written summary
SCFTIR1 contains ASK, AtCUL1 and TIR1.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Gene
- ASK and AtCUL1e0
- Outcome
- complex consists of proteinse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The complex consists of proteins related to yeast Skp1p and Cdc53p called ASK and AtCUL1, respectively, as well as the F-box protein TIR1”
t0“Arabidopsis thaliana”
Claim · model-written summary
ASK1 mutations decrease auxin response.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Treatment
- Mutations in either ASK1 or TIR1e0
- Gene
- ASK1e0
- Outcome
- auxin responsee0
- Direction
- decreasede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Mutations in either ASK1 or TIR1 result in decreased auxin response”
t0“Arabidopsis thaliana”
Claim · model-written summary
TIR1 mutations decrease auxin response.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Treatment
- Mutations in either ASK1 or TIR1e0
- Gene
- TIR1e0
- Outcome
- auxin responsee0
- Direction
- decreasede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Mutations in either ASK1 or TIR1 result in decreased auxin response”
t0“Arabidopsis thaliana”
Claim · model-written summary
TIR1 overexpression promotes auxin response.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Treatment
- overexpression of TIR1e0
- Gene
- TIR1e0
- Outcome
- auxin responsee0
- Direction
- promotese0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“overexpression of TIR1 promotes auxin response suggesting that SCFTIR1 is limiting for the response”
t0“Arabidopsis thaliana”
Claim · model-written summary
SCFTIR1 may limit auxin response.
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Gene
- SCFTIR1e0
- Outcome
- responsee0
- Qualifier
- limiting for the responsee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“overexpression of TIR1 promotes auxin response suggesting that SCFTIR1 is limiting for the response”
t0“Arabidopsis thaliana”
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