Abstract
Several triazole-containing chemicals have previously been shown to act as efficient inhibitors of cytochrome P450 monooxygenases. To discover a strigolactone biosynthesis inhibitor, we screened a chemical library of triazole derivatives to find chemicals that induce tiller bud outgrowth of rice seedlings. We discovered a triazole-type chemical, TIS13 [2,2-dimethyl-7-phenoxy-4-(1H-1,2,4-triazol-1-yl)heptan-3-ol], which induced outgrowth of second tiller buds of wild-type seedlings, as observed for non-treated strigolactone-deficient d10 mutant seedlings. TIS13 treatment reduced strigolactone levels in both roots and root exudates in a concentration-dependent manner. Co-application of GR24, a synthetic strigolactone, with TIS13 canceled the TIS13-induced tiller bud outgrowth. Taken together, these results indicate that TIS13 inhibits strigolactone biosynthesis in rice seedlings. We propose that TIS13 is a new lead compound for the development of specific strigolactone biosynthesis inhibitors.
Abstract from the paper’s OpenAlex record; open copy licensed cc-by-nc. Read at the source ↗
The text the model read, with the source record’s inline markup (italics, sub- and superscripts) rendered and its character entities decoded; quote offsets refer to the raw text.
Claims 6
Claim · model-written summary
TIS13 induced second tiller bud outgrowth in wild-type seedlings.
- Taxon
- rice
Oryza sativae1 - Organ / stage
- second tiller budse0
- Treatment
- TIS13e0
- Outcome
- outgrowth of second tiller budse0
- Direction
- inducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“TIS13 [2,2-dimethyl-7-phenoxy-4-(1H-1,2,4-triazol-1-yl)heptan-3-ol], which induced outgrowth of second tiller buds of wild-type seedlings”
e1“tiller bud outgrowth of rice seedlings”
Claim · model-written summary
TIS13 reduced strigolactone levels in roots in a concentration-dependent manner.
- Taxon
- riceOryza sativae1
- Treatment
- TIS13 treatmente0
- Outcome
- strigolactone levels in both rootse0
- Direction
- reducede0
- Qualifier
- concentration-dependent mannere0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“TIS13 treatment reduced strigolactone levels in both roots and root exudates in a concentration-dependent manner”
e1“tiller bud outgrowth of rice seedlings”
Claim · model-written summary
TIS13 reduced strigolactone levels in root exudates in a concentration-dependent manner.
- Taxon
- riceOryza sativae1
- Treatment
- TIS13 treatmente0
- Outcome
- strigolactone levels in both roots and root exudatese0
- Direction
- reducede0
- Qualifier
- concentration-dependent mannere0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“TIS13 treatment reduced strigolactone levels in both roots and root exudates in a concentration-dependent manner”
e1“tiller bud outgrowth of rice seedlings”
Claim · model-written summary
Co-applied GR24 canceled TIS13-induced tiller bud outgrowth.
- Taxon
- riceOryza sativae1
- Treatment
- Co-application of GR24, a synthetic strigolactone, with TIS13e0
- Outcome
- tiller bud outgrowthe0
- Direction
- cancelede0
- Comparator
- TIS13-inducede0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Co-application of GR24, a synthetic strigolactone, with TIS13 canceled the TIS13-induced tiller bud outgrowth”
e1“tiller bud outgrowth of rice seedlings”
Claim · model-written summary
Authors infer that TIS13 inhibits strigolactone biosynthesis in rice seedlings.
- Taxon
- riceOryza sativae0
- Treatment
- TIS13e0
- Outcome
- strigolactone biosynthesise0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“TIS13 inhibits strigolactone biosynthesis in rice seedlings”
Claim · model-written summary
Authors propose TIS13 as a lead for specific strigolactone biosynthesis inhibitors.
- Taxon
- riceOryza sativae1
- Treatment
- TIS13e0
- Outcome
- new lead compound for the development of specific strigolactone biosynthesis inhibitorse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“TIS13 is a new lead compound for the development of specific strigolactone biosynthesis inhibitors”
e1“tiller bud outgrowth of rice seedlings”
The same questions in other papers
cobalt atom · yield · Oryza sativa (rice)Positive and negative results
10 in the opposite direction
- positive
- positive
- positive
7 papers more in this group
See all 11 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.