Abstract
본 연구는 배의 품종별 생육 단계에 따른 추출물의 총 페놀, 플라보노이드 함량 및 항산화 활성을 확인함과 동시에 세포 독성 및 멜라닌 생합성 억제능을 비교 평가하여 미백 소재로써의 사용 가능성을 평가하고자 국내 육성한 4가지 신품종과 신고 품종을 이용하여 비교 분석하였다. 총 폴리페놀 함량은 생육초기에 가장 높았으나 과일이 성숙할수록 낮아졌으며, 품종간에는 생육시기와 관계없이 추황배에서 높게 나타났다. 총 플라보노이드 함량은 총 폴리페놀보다 적은 함량으로 5품종 모두 생육시기별로 큰 차이를 보이지 않았다. 알부틴은 총 폴리페놀 함량과 같이 과일이 성숙할수록 낮아지는 경향을 보였으며 DPPH, ABTS 라디칼 소거활성을 분석한 항산화 활성도 감소의 폭은 달랐지만 비슷한 경향을 보였다. 높은 항산화 활성은 멜라닌 생합성 억제에도 효과적으로 작용하여 만개 후 90일까지는 감천배를 제외한 4품종에서 50% 내외의 높은 억제 활성을 보여, 이 시기까지의 배 과일 추출물은 우수한 미백활성을 가지는 것으로 확인되었다. 뿐만 아니라 세포독성이 극히 낮아 피부 안정성이 높은 기능성 천연 원료 및 미백 향장소재로써 이용 가능성이 충분한 것으로 판단된다. This study was carried out to investigate the total polyphenols, antioxidant activities, and melanin synthesis inhibition of several pear cultivars (Pyruspyrifolia). The total polypenolic content of five pear cultivars was high in the unripe developmental stage. Total polyphenolic content of the Chuwhangbae cultivar extract was higher than that of other pear cultivars regardless of the developmental stage. However, the total flavonoid content did not differ between cultivars or developmental stages. The phenolic compound, arbutin has an inhibitory effect on melanogenesis. Arbutin levels in pear cultivars declined as the fruit matured. The free radical scavenging activity of the extract also decreased as the fruit ripened. In B16F10 mouse melanoma cells, most of the cultivar extracts inhibited melanin synthesis by about 50% at a $100{\mu}g{\cdot}mL^{-1}$ concentration, except in the Gamcheonbae extract until 90 days after full bloom. We have confirmed that the extract of pear cultivars have antioxidant activity and skin-whitening effects.
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Claims 6
Claim · model-written summary
Total polyphenolic content of five pear cultivars was highest at the unripe developmental stage.
- Taxon
- pear
_Poirier_Fleurs_et_feuilles.jpg?width=60)
Pyrus communise1 - Organ / stage
- unripe developmental stagee1
- Outcome
- total polypenolic contente1
- Direction
- highe1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_Poirier_Fleurs_et_feuilles.jpg?width=500)
Verbatim
e1“The total polypenolic content of five pear cultivars was high in the unripe developmental stage”
Claim · model-written summary
Chuwhangbae cultivar extract had higher total polyphenolic content than other pear cultivars regardless of developmental stage.
- Taxon
- pearPyrus communise2
- Material
- Chuwhangbaee2
- Outcome
- Total polyphenolic contente2
- Direction
- highere2
- Comparator
- other pear cultivarse2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e2“Total polyphenolic content of the Chuwhangbae cultivar extract was higher than that of other pear cultivars regardless of the developmental stage”
Claim · model-written summary
Total flavonoid content did not differ between pear cultivars or developmental stages.
- Taxon
- pearPyrus communise1
- Outcome
- total flavonoid contente3
- Direction
- did not differe3
- Comparator
- between cultivars or developmental stagese3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e3“However, the total flavonoid content did not differ between cultivars or developmental stages”
e1“The total polypenolic content of five pear cultivars was high in the unripe developmental stage”
Claim · model-written summary
Arbutin levels in pear cultivars declined as the fruit matured.
- Taxon
- pearPyrus communise4
- Organ / stage
- fruite4
- Outcome
- Arbutin levelse4
- Direction
- declinede4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e4“Arbutin levels in pear cultivars declined as the fruit matured”
Claim · model-written summary
Free radical scavenging activity of the extract decreased as the fruit ripened.
- Taxon
- pearPyrus communise1
- Organ / stage
- fruite5
- Outcome
- free radical scavenging activitye5
- Direction
- decreasede5
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e5“The free radical scavenging activity of the extract also decreased as the fruit ripened”
e1“The total polypenolic content of five pear cultivars was high in the unripe developmental stage”
Claim · model-written summary
Most pear cultivar extracts inhibited melanin synthesis in B16F10 cells by about 50%, except the Gamcheonbae extract until 90 days after full bloom.
- Taxon
- pearPyrus communise1
- Treatment
- cultivar extractse6
- Outcome
- melanin synthesise6
- Direction
- inhibitede6
- Value
- about 50%e6
- Qualifier
- except in the Gamcheonbae extract until 90 days after full bloome7
- Setting
- B16F10 mouse melanoma cellse6
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e6“In B16F10 mouse melanoma cells, most of the cultivar extracts inhibited melanin synthesis by about 50%”
e7“except in the Gamcheonbae extract until 90 days after full bloom”
e1“The total polypenolic content of five pear cultivars was high in the unripe developmental stage”
The same questions in other papers
botanical · molecular: metabolites · Pyrus communis (pear)Results agree
3 papers in the same direction as this paper
- positive
- positive
- positive
Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.