Abstract
In order to discover the bioactive metabolites of Pyrus ussuriensis Maxim, the systematic chemical and pharmacological investigations were performed. The ethyl acetate extract of the plant displayed activities against ear edema in mice, with an inhibition rate of 17.1%, at a dose of 400mg/kg in vivo. Meanwhile, the ethyl acetate extract showed the best apophlegmatic (inhibition: 49.9%) and antitussive effects (inhibition: 34%) at 800mg/kg in vivo tests, and inhibition of NO production (IC50=0.06 μg/mL). Subsequently, twelve compounds were isolated from the ethyl acetate extract and identified as friedelin (1), daucosterol (2), β-sitosterol (3), betulinic acid (4), oleanolic acid (5), ursolic acid (6), 2-O-buty-1-O’-(2-ethylhexyl) benzene-1,8-dicarboxylate (7), Narcissin (8), 3-hydroxy-3-carboxyl-glutaric acid dimethyl ester (9), 2-hydroxyl -butanediol icacid-4-methyleste (10), myristic acid (11), and (Z)-11-hexadecen-1-ol acetate (12). Among them, compounds 1, 2, 4, 5, 6, and 11 exhibited moderate indirect inhibitory effects on lipopolysaccharide-induced NO and TNF-α production. Practical applications Pyrus ussuriensis Maxim is an edible and medical fruit with many functional properties. Unfortunately, few literatures about bioactive components of this fruit have been investigated. The result indicated that P. ussuriensis have obvious anti-inflammatory, antitussive, and apophlegmatic activities, which were associated with the folk uses of this fruit. Furthermore, this work also suggests a potential use of P. ussuriensis as an important source of natural anti-inflammatory agents and they may also be considered as a functional food.
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Claims 6
Claim · model-written summary
The ethyl acetate extract of pear fruit inhibited ear edema in mice by 17.1% at 400mg/kg in vivo.
- Taxon
- pear
_Poirier_Fleurs_et_feuilles.jpg?width=60)
Pyrus communist0 - Treatment
- ethyl acetate extracte0
- Outcome
- ear edemae0
- Direction
- inhibitione0
- Value
- 17.1%e0
- Qualifier
- at a dose of 400mg/kge0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_Poirier_Fleurs_et_feuilles.jpg?width=500)
Verbatim
e0“The ethyl acetate extract of the plant displayed activities against ear edema in mice, with an inhibition rate of 17.1%, at a dose of 400mg/kg in vivo”
t0“pear”
Claim · model-written summary
The ethyl acetate extract of pear fruit showed apophlegmatic inhibition of 49.9% at 800mg/kg in vivo.
- Taxon
- pearPyrus communist0
- Treatment
- ethyl acetate extracte0
- Outcome
- apophlegmatice0
- Direction
- inhibitione0
- Value
- 49.9%e0
- Qualifier
- 800mg/kge0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the ethyl acetate extract showed the best apophlegmatic (inhibition: 49.9%) and antitussive effects (inhibition: 34%) at 800mg/kg in vivo tests”
t0“pear”
Claim · model-written summary
The ethyl acetate extract of pear fruit showed antitussive inhibition of 34% at 800mg/kg in vivo.
- Taxon
- pearPyrus communist0
- Treatment
- ethyl acetate extracte0
- Outcome
- antitussive effectse0
- Direction
- inhibitione0
- Value
- 34%e0
- Qualifier
- 800mg/kge0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the ethyl acetate extract showed the best apophlegmatic (inhibition: 49.9%) and antitussive effects (inhibition: 34%) at 800mg/kg in vivo tests”
t0“pear”
Claim · model-written summary
The ethyl acetate extract of pear fruit inhibited NO production with an IC50 of 0.06 μg/mL.
- Taxon
- pearPyrus communist0
- Outcome
- NO productione0
- Direction
- inhibitione0
- Value
- IC50=0.06 μg/mLe0
Not reportedTreatmentComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“inhibition of NO production (IC50=0.06 μg/mL)”
t0“pear”
Claim · model-written summary
Twelve compounds, including friedelin, daucosterol, beta-sitosterol and oleanolic acid, were isolated from the ethyl acetate extract of pear fruit.
- Taxon
- pearPyrus communist0
- Outcome
- twelve compoundse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“twelve compounds were isolated from the ethyl acetate extract”
t0“pear”
Claim · model-written summary
Isolated compounds 1, 2, 4, 5, 6 and 11 had moderate indirect inhibitory effects on lipopolysaccharide-induced NO and TNF-α production.
- Taxon
- pearPyrus communist0
- Outcome
- lipopolysaccharide-induced NO and TNF-α productione0
- Qualifier
- moderate indirect inhibitory effectse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“compounds 1, 2, 4, 5, 6, and 11 exhibited moderate indirect inhibitory effects on lipopolysaccharide-induced NO and TNF-α production”
t0“pear”
The same questions in other papers
botanical · molecular: metabolites · Pyrus communis (pear)Results agree
3 papers in the same direction as this paper
- positive
- positive
- positive
Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.