Abstract
The phytohormone 7-iso-(+)-jasmonoyl-L-isoleucine (JA-Ile) mediates plant defense responses against herbivore and pathogen attack, and thus increases plant resistance against foreign invaders. However, JA-Ile also causes growth inhibition; and therefore JA-Ile is not a practical chemical regulator of plant defense responses. Here, we describe the rational design and synthesis of a small molecule agonist that can upregulate defense-related gene expression and promote pathogen resistance at concentrations that do not cause growth inhibition in Arabidopsis. By stabilizing interactions between COI1 and JAZ9 and JAZ10 but no other JAZ isoforms, the agonist leads to formation of JA-Ile co-receptors that selectively activate the JAZ9-EIN3/EIL1-ORA59 signaling pathway. The design of a JA-Ile agonist with high selectivity for specific protein subtypes may help promote the development of chemical regulators that do not cause a tradeoff between growth and defense.
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Claims 5
Claim · model-written summary
The agonist upregulated defence-related gene expression in Arabidopsis.
- Taxon
- Arabidopsis
Arabidopsise1 - Treatment
- small molecule agoniste1
- Outcome
- defense-related gene expressione1
- Direction
- upregulatee1
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“a small molecule agonist that can upregulate defense-related gene expression and promote pathogen resistance at concentrations that do not cause growth inhibition in Arabidopsis”
Claim · model-written summary
The agonist promoted pathogen resistance in Arabidopsis.
- Taxon
- ArabidopsisArabidopsise1
- Treatment
- small molecule agoniste1
- Outcome
- pathogen resistancee1
- Direction
- promotee1
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“a small molecule agonist that can upregulate defense-related gene expression and promote pathogen resistance at concentrations that do not cause growth inhibition in Arabidopsis”
Claim · model-written summary
The agonist, at effective concentrations, does not cause growth inhibition in Arabidopsis, unlike JA-Ile.
- Taxon
- ArabidopsisArabidopsise1
- Treatment
- small molecule agoniste1
- Outcome
- growth inhibitione1
- Direction
- do not causee1
- Comparator
- JA-Ilee3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“a small molecule agonist that can upregulate defense-related gene expression and promote pathogen resistance at concentrations that do not cause growth inhibition in Arabidopsis”
e3“JA-Ile also causes growth inhibition”
Claim · model-written summary
The agonist stabilised interactions between COI1 and JAZ9 and JAZ10 but not other JAZ isoforms.
- Taxon
- ArabidopsisArabidopsise1
- Treatment
- agoniste2
- Gene
- JAZ9 and JAZ10e2
- Outcome
- interactions between COI1 and JAZ9 and JAZ10e2
- Direction
- stabilizinge2
- Comparator
- other JAZ isoformse2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“a small molecule agonist that can upregulate defense-related gene expression and promote pathogen resistance at concentrations that do not cause growth inhibition in Arabidopsis”
e2“By stabilizing interactions between COI1 and JAZ9 and JAZ10 but no other JAZ isoforms, the agonist leads to formation of JA-Ile co-receptors that selectively activate the JAZ9-EIN3/EIL1-ORA59 signaling pathway”
Claim · model-written summary
The agonist selectively activates the JAZ9-EIN3/EIL1-ORA59 signalling pathway, which explains the defence response.
- Taxon
- ArabidopsisArabidopsise1
- Gene
- JAZ9-EIN3/EIL1-ORA59e2
- Outcome
- selectively activate the JAZ9-EIN3/EIL1-ORA59 signaling pathwaye2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“a small molecule agonist that can upregulate defense-related gene expression and promote pathogen resistance at concentrations that do not cause growth inhibition in Arabidopsis”
e2“By stabilizing interactions between COI1 and JAZ9 and JAZ10 but no other JAZ isoforms, the agonist leads to formation of JA-Ile co-receptors that selectively activate the JAZ9-EIN3/EIL1-ORA59 signaling pathway”
The same questions in other papers
agonist · molecular: expression · ArabidopsisResults agree
1 paper in the same direction as this paper
- positive
Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.