Abstract
The previously reported Arabidopsis dominant gain-of-function mutant accelerated cell death6-1 (acd6-1) shows spontaneous cell death and increased disease resistance. acd6-1 also confers increased responsiveness to the major defense signal salicylic acid (SA). To further explore the role of ACD6 in the defense response, we cloned and characterized the gene. ACD6 encodes a novel protein with putative ankyrin and transmembrane regions. It is a member of one of the largest uncharacterized gene families in higher plants. Steady state basal expression of ACD6 mRNA required light, SA, and an intact SA signaling pathway. Additionally, ACD6 mRNA levels were increased in the systemic, uninfected tissue of Pseudomonas syringae-infected plants as well as in plants treated with the SA agonist benzothiazole (BTH). A newly isolated ACD6 loss-of-function mutant was less responsive to BTH and upon P. syringae infection had reduced SA levels and increased susceptibility. Conversely, plants overexpressing ACD6 showed modestly increased SA levels, increased resistance to P. syringae, and BTH-inducible and/or a low level of spontaneous cell death. Thus, ACD6 is a necessary and dose-dependent activator of the defense response against virulent bacteria and can activate SA-dependent cell death.
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Claims 11
Claim · model-written summary
Basal expression of ACD6 mRNA in Arabidopsis required light, SA and an intact SA signaling pathway.
- Taxon
- Arabidopsis
Arabidopsist0 - Treatment
- light, SA, and an intact SA signaling pathwaye1
- Gene
- ACD6e1
- Outcome
- Steady state basal expression of ACD6 mRNAe1
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis Defense Response”
e1“Steady state basal expression of ACD6 mRNA required light, SA, and an intact SA signaling pathway”
Claim · model-written summary
ACD6 mRNA levels increased in systemic, uninfected tissue of P. syringae-infected Arabidopsis plants.
- Taxon
- ArabidopsisArabidopsist0
- Organ / stage
- systemic, uninfected tissuee2
- Treatment
- Pseudomonas syringae-infected plantse2
- Interactor
- Pseudomonas syringae
Pseudomonas syringaee2pathogen - Gene
- ACD6e2
- Outcome
- ACD6 mRNA levelse2
- Direction
- increasede2
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis Defense Response”
e2“ACD6 mRNA levels were increased in the systemic, uninfected tissue of Pseudomonas syringae-infected plants as well as in plants treated with the SA agonist benzothiazole (BTH)”
Claim · model-written summary
ACD6 mRNA levels increased in Arabidopsis plants treated with the SA agonist BTH.
- Taxon
- ArabidopsisArabidopsist0
- Treatment
- the SA agonist benzothiazole (BTH)e2
- Gene
- ACD6e2
- Outcome
- ACD6 mRNA levelse2
- Direction
- increasede2
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis Defense Response”
e2“ACD6 mRNA levels were increased in the systemic, uninfected tissue of Pseudomonas syringae-infected plants as well as in plants treated with the SA agonist benzothiazole (BTH)”
Claim · model-written summary
The ACD6 loss-of-function mutant was less responsive to BTH.
- Taxon
- ArabidopsisArabidopsist0
- Material
- ACD6 loss-of-function mutante3
- Treatment
- BTHe3
- Outcome
- responsivee3
- Direction
- lesse3
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis Defense Response”
e3“A newly isolated ACD6 loss-of-function mutant was less responsive to BTH and upon P. syringae infection had reduced SA levels and increased susceptibility”
Claim · model-written summary
The ACD6 loss-of-function mutant had reduced SA levels upon P. syringae infection.
- Taxon
- ArabidopsisArabidopsist0
- Material
- ACD6 loss-of-function mutante3
- Treatment
- P. syringae infectione3
- Interactor
- P. syringaePseudomonas syringaee3pathogen
- Compound
- SAe3
- Outcome
- SA levelse3
- Direction
- reducede3
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis Defense Response”
e3“A newly isolated ACD6 loss-of-function mutant was less responsive to BTH and upon P. syringae infection had reduced SA levels and increased susceptibility”
Claim · model-written summary
The ACD6 loss-of-function mutant had increased susceptibility upon P. syringae infection.
- Taxon
- ArabidopsisArabidopsist0
- Material
- ACD6 loss-of-function mutante3
- Treatment
- P. syringae infectione3
- Interactor
- P. syringaePseudomonas syringaee3pathogen
- Outcome
- susceptibilitye3
- Direction
- increasede3
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis Defense Response”
e3“A newly isolated ACD6 loss-of-function mutant was less responsive to BTH and upon P. syringae infection had reduced SA levels and increased susceptibility”
Claim · model-written summary
Overexpressing ACD6 modestly increased SA levels in Arabidopsis.
- Taxon
- ArabidopsisArabidopsist0
- Treatment
- overexpressing ACD6e4
- Compound
- SAe4
- Outcome
- SA levelse4
- Direction
- modestly increasede4
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis Defense Response”
e4“plants overexpressing ACD6 showed modestly increased SA levels, increased resistance to P. syringae, and BTH-inducible and/or a low level of spontaneous cell death”
Claim · model-written summary
Overexpressing ACD6 increased resistance to P. syringae in Arabidopsis.
- Taxon
- ArabidopsisArabidopsist0
- Treatment
- overexpressing ACD6e4
- Interactor
- P. syringaePseudomonas syringaee4pathogen
- Outcome
- resistancee4
- Direction
- increasede4
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis Defense Response”
e4“plants overexpressing ACD6 showed modestly increased SA levels, increased resistance to P. syringae, and BTH-inducible and/or a low level of spontaneous cell death”
Claim · model-written summary
Plants overexpressing ACD6 showed BTH-inducible and/or a low level of spontaneous cell death.
- Taxon
- ArabidopsisArabidopsist0
- Material
- plants overexpressing ACD6e4
- Outcome
- spontaneous cell deathe4
- Qualifier
- BTH-inducible and/or a low levele4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis Defense Response”
e4“plants overexpressing ACD6 showed modestly increased SA levels, increased resistance to P. syringae, and BTH-inducible and/or a low level of spontaneous cell death”
Claim · model-written summary
ACD6 is a necessary and dose-dependent activator of the defense response in Arabidopsis against virulent bacteria.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- ACD6e5
- Outcome
- defense response against virulent bacteriae5
- Qualifier
- necessary and dose-dependente5
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis Defense Response”
e5“ACD6 is a necessary and dose-dependent activator of the defense response against virulent bacteria and can activate SA-dependent cell death”
Claim · model-written summary
ACD6 can activate SA-dependent cell death in Arabidopsis.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- ACD6e5
- Outcome
- SA-dependent cell deathe5
- Qualifier
- can activatee5
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis Defense Response”
e5“ACD6 is a necessary and dose-dependent activator of the defense response against virulent bacteria and can activate SA-dependent cell death”
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Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.