Abstract
Since the 50’s, the massive and “environmental naïve” use of synthetic chemistry has revolutionized the farming community facing the dramatic growth of demography. However, nowadays, the controversy grows regarding the long-term harmful effects of these products on human health and the environment. In this context, the use of essential oils (EOs) could be an alternative to chemical products and a better understanding of their mode of biological action for new and optimal applications is of importance. Indeed, if the biocidal effects of some EOs or their components have been at least partly elucidated at the molecular level, very little is currently known regarding their mechanism of action as herbicides at the molecular level. Here, we showed that cinnamon and Java citronella essential oils and some of their main components, i.e.,, cinnamaldehyde (CIN), citronellal (CitA), and citronellol (CitO) could act as efficient herbicides when spread on A. thaliana leaves. The individual EO molecules are small amphiphiles, allowing for them to cross the mesh of cell wall and directly interact with the plant plasma membrane (PPM), which is one of the potential cellular targets of EOs. Hence, we investigated and characterized their interaction with biomimetic PPM while using an integrative biophysical approach. If CitO and CitA, maintaining a similar chemical structure, are able to interact with the model membranes without permeabilizing effect, CIN belonging to the phenylpropanoid family, is not. We suggested that different mechanisms of action for the two types of molecules can occur: while the monoterpenes could disturb the lipid organization and/or domain formation, the phenylpropanoid CIN could interact with membrane receptors.
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Claims 8
Claim · model-written summary
Cinnamon essential oil acted as an herbicide on A. thaliana leaves.
Not reportedComparatorDirection
Verbatim
e0“cinnamon and Java citronella essential oils and some of their main components, i.e.,, cinnamaldehyde (CIN), citronellal (CitA), and citronellol (CitO) could act as efficient herbicides when spread on A. thaliana leaves.”
Claim · model-written summary
Java citronella essential oil acted as an herbicide on A. thaliana leaves.
Not reportedComparatorDirection
Verbatim
e0“cinnamon and Java citronella essential oils and some of their main components, i.e.,, cinnamaldehyde (CIN), citronellal (CitA), and citronellol (CitO) could act as efficient herbicides when spread on A. thaliana leaves.”
Claim · model-written summary
Cinnamaldehyde could act as an herbicide on A. thaliana leaves.
Not reportedComparatorDirection
Verbatim
e0“cinnamaldehyde (CIN), citronellal (CitA), and citronellol (CitO) could act as efficient herbicides when spread on A. thaliana leaves.”
Claim · model-written summary
Citronellal could act as an herbicide on A. thaliana leaves.
Not reportedComparatorDirection
Verbatim
e0“cinnamaldehyde (CIN), citronellal (CitA), and citronellol (CitO) could act as efficient herbicides when spread on A. thaliana leaves.”
Claim · model-written summary
Citronellol could act as an herbicide on A. thaliana leaves.
Not reportedComparatorDirection
Verbatim
e0“cinnamaldehyde (CIN), citronellal (CitA), and citronellol (CitO) could act as efficient herbicides when spread on A. thaliana leaves.”
Claim · model-written summary
Citronellol interacted with model plant plasma membranes without permeabilizing them.
- Taxon
- A. thalianae3
- Treatment
- citronellol (CitO)e2
- Outcome
- interact with the model membranes without permeabilizing effecte0
Not reportedDirection
Verbatim
e0“CitO and CitA, maintaining a similar chemical structure, are able to interact with the model membranes without permeabilizing effect”
e1“plant plasma membrane (PPM)”
e2“citronellol (CitO)”
e3“A. thaliana leaves”
Claim · model-written summary
Citronellal interacted with model plant plasma membranes without permeabilizing them.
- Taxon
- A. thalianae2
- Treatment
- citronellal (CitA)e1
- Outcome
- interact with the model membranes without permeabilizing effecte0
Not reportedDirection
Verbatim
e0“CitO and CitA, maintaining a similar chemical structure, are able to interact with the model membranes without permeabilizing effect”
e1“citronellal (CitA)”
e2“A. thaliana leaves”
Claim · model-written summary
Cinnamaldehyde did not show the reported interaction with model membranes.
Not reportedDirection
Verbatim
e0“CIN belonging to the phenylpropanoid family, is not”
e1“cinnamaldehyde (CIN)”
e2“A. thaliana leaves”
The same questions in other papers
(E)-cinnamaldehyde · molecular: metabolites · Arabidopsis thaliana (thale cress)Positive and negative results
1 in the opposite direction
- negative
botanical · molecular: metabolites · Arabidopsis thaliana (thale cress)Positive and negative results
1 paper in the same direction as this paper · 1 in the opposite direction
- negative
- positive
Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.