Abstract
Fumarylacetoacetate hydrolase (FAH) catalyzes the final step in Tyr degradation pathway essential to animals but not well understood in plants. Previously, we found that mutation of SSCD1 encoding Arabidopsis FAH causes cell death under short day, which uncovered an important role of Tyr degradation pathway in plants. Since phytohormones salicylic acid (SA) and jasmonate (JA) are involved in programmed cell death, in this study, we investigated whether sscd1 cell death is related to SA and JA, and found that (1) it is accompanied by up-regulation of JA- and SA-inducible genes as well as accumulation of JA but not SA; (2) it is repressed by breakdown of JA signaling but not SA signaling; (3) the up-regulation of reactive oxygen species marker genes in sscd1 is repressed by breakdown of JA signaling; (4) treatment of wild-type Arabidopsis with succinylacetone, an abnormal metabolite caused by loss of FAH, induces expression of JA-inducible genes whereas treatment with JA induces expression of some Tyr degradation genes with dependence of JA signaling. These results demonstrated that cell death resulted from loss of FAH in Arabidopsis is related to JA but not SA, and suggested that JA signaling positively regulates sscd1 cell death by up-regulating Tyr degradation.
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Claims 8
Claim · model-written summary
sscd1 cell death accompanies upregulation of JA- and SA-inducible genes.
- Taxon
- Arabidopsis
Arabidopsist0 - Material
- sscd1e1
- Outcome
- up-regulation of JA- and SA-inducible genese0
- Direction
- up-regulatione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“it is accompanied by up-regulation of JA- and SA-inducible genes”
t0“Arabidopsis”
e1“the up-regulation of reactive oxygen species marker genes in sscd1”
Claim · model-written summary
sscd1 cell death accompanies JA accumulation but not SA accumulation.
- Taxon
- ArabidopsisArabidopsist0
- Material
- sscd1e1
- Outcome
- accumulation of JA but not SAe0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“accumulation of JA but not SA”
t0“Arabidopsis”
e1“the up-regulation of reactive oxygen species marker genes in sscd1”
Claim · model-written summary
Breaking down JA signaling represses sscd1 cell death.
- Taxon
- ArabidopsisArabidopsist0
- Treatment
- breakdown of JA signalinge0
- Outcome
- cell deatht0
- Direction
- repressede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“it is repressed by breakdown of JA signaling but not SA signaling”
t0“Cell death resulted from loss of fumarylacetoacetate hydrolase in Arabidopsis”
Claim · model-written summary
Breaking down SA signaling does not repress sscd1 cell death.
- Taxon
- ArabidopsisArabidopsist0
- Treatment
- SA signalinge0
- Outcome
- cell deatht0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“it is repressed by breakdown of JA signaling but not SA signaling”
t0“Cell death resulted from loss of fumarylacetoacetate hydrolase in Arabidopsis”
Claim · model-written summary
Breaking down JA signaling represses upregulation of reactive oxygen species marker genes in sscd1.
- Taxon
- ArabidopsisArabidopsist0
- Material
- sscd1e0
- Treatment
- breakdown of JA signalinge0
- Outcome
- up-regulation of reactive oxygen species marker genese0
- Direction
- repressede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the up-regulation of reactive oxygen species marker genes in sscd1 is repressed by breakdown of JA signaling”
t0“Arabidopsis”
Claim · model-written summary
Succinylacetone induces JA-inducible genes in wild-type Arabidopsis.
- Taxon
- ArabidopsisArabidopsise0
- Material
- wild-typee0
- Treatment
- succinylacetonee0
- Outcome
- expression of JA-inducible genese0
- Direction
- inducese0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“treatment of wild-type Arabidopsis with succinylacetone, an abnormal metabolite caused by loss of FAH, induces expression of JA-inducible genes”
Claim · model-written summary
JA induces some Tyr degradation genes with dependence on JA signaling.
- Taxon
- ArabidopsisArabidopsist0
- Treatment
- JAe0
- Outcome
- expression of some Tyr degradation genese0
- Direction
- inducese0
- Qualifier
- dependence of JA signalinge0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“treatment with JA induces expression of some Tyr degradation genes with dependence of JA signaling”
t0“Arabidopsis”
Claim · model-written summary
JA signaling may positively regulate sscd1 cell death through upregulation of Tyr degradation.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- JA signalinge0
- Outcome
- sscd1 cell deathe0
- Qualifier
- up-regulating Tyr degradatione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“suggested that JA signaling positively regulates sscd1 cell death by up-regulating Tyr degradation”
t0“Arabidopsis”
The same questions in other papers
salicylic acid · cytology · ArabidopsisPositive and negative results
2 papers in the same direction as this paper · 2 in the opposite direction
- positive
- no effect
- positive
1 paper more in this group
See all 5 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.