Abstract
Rice stripe virus (RSV) is one of the most destructive viral diseases affecting rice production. However, so far, only one RSV resistance gene has been cloned, the molecular mechanisms underlying host-RSV interaction are still poorly understood. Here, we show that increasing levels or signaling of brassinosteroids (BR) and jasmonic acid (JA) can significantly enhance the resistance against RSV. On the contrary, plants impaired in BR or JA signaling are more susceptible to RSV. Moreover, the enhancement of RSV resistance conferred by BR is impaired in OsMYC2 (a key positive regulator of JA response) knockout plants, suggesting that BR-mediated RSV resistance requires active JA pathway. In addition, we found that RSV infection suppresses the endogenous BR levels to increase the accumulation of OsGSK2, a key negative regulator of BR signaling. OsGSK2 physically interacts with OsMYC2, resulting in the degradation of OsMYC2 by phosphorylation and reduces JA-mediated defense to facilitate virus infection. These findings not only reveal a novel molecular mechanism mediating the crosstalk between BR and JA in response to virus infection and deepen our understanding about the interaction of virus and plants, but also suggest new effective means of breeding RSV resistant crops using genetic engineering.
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Claims 10
Claim · model-written summary
Increasing brassinosteroid levels or signaling significantly enhanced rice resistance against RSV.
- Taxon
- rice
Oryza sativat0 - Treatment
- increasing levels or signaling of brassinosteroids (BR)e0
- Interactor
- RSVe0pathogen
- Outcome
- resistance against RSVe0
- Direction
- enhancee0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“increasing levels or signaling of brassinosteroids (BR) and jasmonic acid (JA) can significantly enhance the resistance against RSV”
t0“in rice”
Claim · model-written summary
Increasing jasmonic acid levels or signaling significantly enhanced rice resistance against RSV.
- Taxon
- riceOryza sativat0
- Treatment
- jasmonic acid (JA)e0
- Interactor
- RSVe0pathogen
- Outcome
- resistance against RSVe0
- Direction
- enhancee0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“increasing levels or signaling of brassinosteroids (BR) and jasmonic acid (JA) can significantly enhance the resistance against RSV”
t0“in rice”
Claim · model-written summary
Plants impaired in BR signaling were more susceptible to RSV.
- Taxon
- riceOryza sativat0
- Interactor
- RSVe0pathogen
- Outcome
- susceptible to RSVe0
- Direction
- more susceptiblee0
Not reportedGene
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“plants impaired in BR or JA signaling are more susceptible to RSV”
t0“in rice”
Claim · model-written summary
Plants impaired in JA signaling were more susceptible to RSV.
- Taxon
- riceOryza sativat0
- Interactor
- RSVe0pathogen
- Outcome
- susceptible to RSVe0
- Direction
- more susceptiblee0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“plants impaired in BR or JA signaling are more susceptible to RSV”
t0“in rice”
Claim · model-written summary
BR-conferred RSV resistance was impaired in OsMYC2 knockout rice.
- Taxon
- riceOryza sativat0
- Treatment
- OsMYC2 (a key positive regulator of JA response) knockoute0
- Interactor
- RSVe0pathogen
- Gene
- OsMYC2e0
- Outcome
- enhancement of RSV resistance conferred by BRe0
- Direction
- impairede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“enhancement of RSV resistance conferred by BR is impaired in OsMYC2 (a key positive regulator of JA response) knockout plants”
t0“in rice”
Claim · model-written summary
RSV infection suppressed endogenous BR levels in rice.
- Taxon
- riceOryza sativat0
- Treatment
- RSV infectione0
- Interactor
- RSVe0pathogen
- Outcome
- endogenous BR levelse0
- Direction
- suppressese0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“RSV infection suppresses the endogenous BR levels”
t0“in rice”
Claim · model-written summary
RSV infection increased accumulation of OsGSK2 in rice.
- Taxon
- riceOryza sativat0
- Treatment
- RSV infectione0
- Interactor
- RSVe0pathogen
- Gene
- OsGSK2e0
- Outcome
- accumulation of OsGSK2e0
- Direction
- increasee0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“RSV infection suppresses the endogenous BR levels to increase the accumulation of OsGSK2”
t0“in rice”
Claim · model-written summary
OsGSK2 physically interacts with OsMYC2.
- Taxon
- riceOryza sativat0
- Gene
- OsGSK2e0
- Outcome
- physically interacts with OsMYC2e0
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“OsGSK2 physically interacts with OsMYC2”
t0“in rice”
Claim · model-written summary
OsGSK2 interaction phosphorylates and degrades OsMYC2.
- Taxon
- riceOryza sativat0
- Gene
- OsGSK2e0
- Outcome
- degradation of OsMYC2 by phosphorylatione0
- Direction
- degradatione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“OsGSK2 physically interacts with OsMYC2, resulting in the degradation of OsMYC2 by phosphorylation”
t0“in rice”
Claim · model-written summary
OsGSK2 mediated OsMYC2 degradation reduced JA defense and facilitated virus infection.
- Taxon
- riceOryza sativat0
- Interactor
- viruse0pathogen
- Gene
- OsMYC2e0
- Outcome
- JA-mediated defensee0
- Direction
- reducese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“degradation of OsMYC2 by phosphorylation and reduces JA-mediated defense to facilitate virus infection”
t0“in rice”
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See all 11 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.