Abstract
Setaria megaphylla a medicinal plant, used in ethnomedicine for the treatment of malaria, diabetes and inflammatory diseases was investigated for cytotoxic and genotoxic effects on cells of the root meristem of Allium cepa. Bulbs of Onion were exposed to 2.5 mg/ml, 5mg/ml, and 10 mg/ml concentrations of the leaf extract for macroscopic and microscopic study. Tap water was used as a negative control and Methotrexate (0.1 mg/ml) as a positive control. Depending on concentration by the extract, there was statistically significant (P < .05) inhibition of root growth when compared with the negative control group. All the tested concentrations of the extract were observed to have cytotoxic effects on cell division in A. cepa. The extract- induced micronuclei (MNC) formations and chromosomal aberrations in A. cepa root tip cells were significant (P < .05) when compared with control group. The extract treatment further induced, ghost cells, cells membrane damage, cell death, and bi nucleated cells. These results implies that Setaria megaphylla leaf extract possess cytotoxic and genotoxic effects on A. cepa which is as a results of its phytochemical constituents.
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Claims 6
Claim · model-written summary
Extract inhibited onion root growth in a concentration-dependent manner.
- Taxon
- Allium cepa
Allium cepae1 - Treatment
- extracte0
- Outcome
- root growthe0
- Direction
- inhibitione0
- Comparator
- negative control groupe0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Depending on concentration by the extract, there was statistically significant (P < .05) inhibition of root growth when compared with the negative control group”
e1“root meristem of Allium cepa”
Claim · model-written summary
Every tested extract concentration had cytotoxic effects on onion cell division.
- Taxon
- A. cepaAllium cepae0
- Treatment
- extracte0
- Outcome
- cell divisione0
- Direction
- cytotoxic effectse0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“All the tested concentrations of the extract were observed to have cytotoxic effects on cell division in A. cepa”
Claim · model-written summary
Extract induced micronuclei formation in onion root tips.
- Taxon
- A. cepaAllium cepae0
- Treatment
- extracte0
- Outcome
- micronuclei (MNC) formationse0
- Direction
- inducede0
- Comparator
- control groupe0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The extract- induced micronuclei (MNC) formations and chromosomal aberrations in A. cepa root tip cells were significant (P < .05) when compared with control group”
Claim · model-written summary
Extract induced chromosomal aberrations in onion root tips.
- Taxon
- A. cepaAllium cepae0
- Treatment
- extracte0
- Outcome
- chromosomal aberrationse0
- Direction
- inducede0
- Comparator
- control groupe0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The extract- induced micronuclei (MNC) formations and chromosomal aberrations in A. cepa root tip cells were significant (P < .05) when compared with control group”
Claim · model-written summary
Extract induced ghost cells, membrane damage and cell death.
- Taxon
- A. cepaAllium cepae1
- Treatment
- extract treatmente0
- Outcome
- ghost cells, cells membrane damage, cell deathe0
- Direction
- inducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The extract treatment further induced, ghost cells, cells membrane damage, cell death, and bi nucleated cells”
e1“All the tested concentrations of the extract were observed to have cytotoxic effects on cell division in A. cepa”
t0“Genotoxic and Cytotoxicity Activities of Leaf Extract of Setaria megaphylla”
Claim · model-written summary
Extract induced binucleated cells.
- Taxon
- A. cepaAllium cepae1
- Treatment
- extract treatmente0
- Outcome
- bi nucleated cellse0
- Direction
- inducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The extract treatment further induced, ghost cells, cells membrane damage, cell death, and bi nucleated cells”
e1“All the tested concentrations of the extract were observed to have cytotoxic effects on cell division in A. cepa”
t0“Genotoxic and Cytotoxicity Activities of Leaf Extract of Setaria megaphylla”
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