Abstract
Histone H2B ubiquitination (H2Bub) is positively linked to transcriptional activation, but the genetic programs affected by H2Bub to enhance drought tolerance remain largely unknown. Here, we show that OsbZIP27 interacts directly with OsHUB1/2 to regulate drought tolerance in rice by binding to the promoters of OsHAK1 and OsGLN1 to achieve H2Bub and transcriptional activation. Consistently, mutations in OsbZIP27 reduce transcription of OsHAK1 and OsGLN1, resulting in increased sensitivity to drought stress. Moreover, loss of OsHUB1 and OsHUB2 function causes hypersensitivity to drought stress, whereas OsHUB2 overexpression enhances drought tolerance. Together, our results indicate that OsbZIP27 coordinates with OsHUB1/2 to enhance rice drought tolerance by increasing H2Bub and expression of OsHAK1 and OsGLN1.
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Claims 7
Claim · model-written summary
Mutations in OsbZIP27 reduce transcription of OsHAK1 and OsGLN1
- Taxon
- rice
Oryza sativat0 - Treatment
- mutations in OsbZIP27e1
- Gene
- OsHAK1 and OsGLN1e1
- Outcome
- transcription of OsHAK1 and OsGLN1e1
- Direction
- reducee1
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“modulate drought tolerance in rice”
e1“mutations in OsbZIP27 reduce transcription of OsHAK1 and OsGLN1, resulting in increased sensitivity to drought stress”
Claim · model-written summary
Mutations in OsbZIP27 increase sensitivity to drought stress
- Taxon
- riceOryza sativat0
- Treatment
- mutations in OsbZIP27e1
- Gene
- OsbZIP27e1
- Outcome
- sensitivity to drought stresse1
- Direction
- increasede1
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“modulate drought tolerance in rice”
e1“mutations in OsbZIP27 reduce transcription of OsHAK1 and OsGLN1, resulting in increased sensitivity to drought stress”
Claim · model-written summary
Loss of OsHUB1 and OsHUB2 function causes hypersensitivity to drought stress
- Taxon
- riceOryza sativat0
- Treatment
- loss of OsHUB1 and OsHUB2 functione2
- Gene
- OsHUB1 and OsHUB2e2
- Outcome
- hypersensitivity to drought stresse2
- Direction
- increaseinferrede2
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“modulate drought tolerance in rice”
e2“loss of OsHUB1 and OsHUB2 function causes hypersensitivity to drought stress”
Claim · model-written summary
OsHUB2 overexpression enhances drought tolerance
- Taxon
- riceOryza sativat0
- Treatment
- OsHUB2 overexpressione3
- Gene
- OsHUB2e3
- Outcome
- drought tolerancee3
- Direction
- enhancese3
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“modulate drought tolerance in rice”
e3“whereas OsHUB2 overexpression enhances drought tolerance”
Claim · model-written summary
OsbZIP27 interacts directly with OsHUB1/2
- Taxon
- riceOryza sativat0
- Gene
- OsbZIP27e4
- Outcome
- interacts directly with OsHUB1/2e4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“modulate drought tolerance in rice”
e4“OsbZIP27 interacts directly with OsHUB1/2”
Claim · model-written summary
OsbZIP27 binds to the promoters of OsHAK1 and OsGLN1 to achieve H2Bub and transcriptional activation
- Taxon
- riceOryza sativat0
- Gene
- OsHAK1 and OsGLN1e5
- Outcome
- binding to the promoterse5
- Qualifier
- to achieve H2Bub and transcriptional activatione5
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“modulate drought tolerance in rice”
e5“by binding to the promoters of OsHAK1 and OsGLN1 to achieve H2Bub and transcriptional activation”
Claim · model-written summary
OsbZIP27 coordinates with OsHUB1/2 to enhance rice drought tolerance by increasing H2Bub and expression of OsHAK1 and OsGLN1
- Taxon
- riceOryza sativae6
- Gene
- OsbZIP27e6
- Outcome
- drought tolerancee6
- Qualifier
- by increasing H2Bub and expression of OsHAK1 and OsGLN1e6
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e6“OsbZIP27 coordinates with OsHUB1/2 to enhance rice drought tolerance by increasing H2Bub and expression of OsHAK1 and OsGLN1”
The same questions in other papers
loss of function · molecular: expression · Oryza sativa (rice)Positive and negative results
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