Abstract
Abstract Background Tuberculosis is still a serious threat to public health in Africa and especially in the Democratic Republic of Congo, which is one of the eight countries with approximately two-thirds of the global cases of tuberculosis. Given the difficulties in accessing health care services and antitubercular treatments, indigenous population also uses plant-based traditional medicine. This study aimed to identify plants with antituberculosis potential in traditional Katangese medicine. Methods Interviews were conducted on traditional healers using snowball sampling method. Ethnobotanical data were assessed by determination of the informant consensus factor and the relative frequency of citation. Guided field walks allowed to collect plants. Methanolic extracts were tested on Mycobacterium smegmatis and Mycobacterium bovis BCG using microdilution, diffusion and agar proportion methods. The cytotoxicity of the best extracts was evaluated by cell viability assay on the human cervical squamous carcinoma SiHa cell line. The 50% inhibitory concentration and minimal inhibitory concentration (MIC) were used to determine the selectivity index. Results Thirty-eight plant species from 23 families were identified, most of which were from Fabaceae (16%). Eleven out of 17 plant extracts inhibited the growth of M. smegmatis at MIC ranging from 13 to 250 μg/mL. The methanolic extracts of Zanthoxylum chalybeum and Parinari curatellifolia showed MIC 99 of 62.5 and 62.5–125 μg/mL, respectively, on M. bovis BCG and showed IC 50 values of 28 and 20 μg/mL, respectively suggesting a low selectivity index. This study was the first to investigate the antimycobacterial activity of Terminalia mollis , Phyllanthus muellerianus , Ochna afzelii , and Rothmannia engleriana. Conclusions The demonstration of antimycobacterial activity in the plants used in Lubumbashi against tuberculosis opens opportunities for more in-depth research into their chemical composition and toxicity, ultimately aiming to enhance their safety for treatment of tuberculosis.
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Claims 7
Claim · model-written summary
Thirty-eight plant species from 23 families were identified in the ethnobotanical survey.
- Taxon
- plantsViridiplantaet0
- Outcome
- plant speciese1
- Value
- Thirty-eighte1
Verbatim
t0“Ethnobotanical survey and antimycobacterial activities of plants used against tuberculosis”
e1“Thirty-eight plant species from 23 families were identified”
Claim · model-written summary
Eleven of 17 plant extracts inhibited the growth of M. smegmatis at MIC 13 to 250 μg/mL.
- Taxon
- plantsViridiplantaet0
- Treatment
- plant extractse2
- Interactor
- M. smegmatise2other
- Outcome
- growthe2
- Direction
- inhibitede2
- Value
- 13 to 250 μg/mLe2
Not reportedComparator
Verbatim
t0“Ethnobotanical survey and antimycobacterial activities of plants used against tuberculosis”
e2“Eleven out of 17 plant extracts inhibited the growth of M. smegmatis at MIC ranging from 13 to 250 μg/mL”
Claim · model-written summary
Methanolic extract of Zanthoxylum chalybeum had MIC 99 of 62.5 μg/mL on M. bovis BCG.
- Taxon
- Zanthoxylum chalybeum
Zanthoxylum chalybeume3 - Interactor
- M. bovis BCG
Mycobacterium tuberculosis variant bovise3other - Outcome
- MIC 99e3
- Value
- 62.5e3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e3“The methanolic extracts of Zanthoxylum chalybeum and Parinari curatellifolia showed MIC 99 of 62.5 and 62.5–125 μg/mL, respectively, on M. bovis BCG”
Claim · model-written summary
Methanolic extract of Zanthoxylum chalybeum had IC 50 of 28 μg/mL.
- Taxon
- Zanthoxylum chalybeumZanthoxylum chalybeume3
- Outcome
- IC 50 valuese4
- Value
- 28e4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e3“The methanolic extracts of Zanthoxylum chalybeum and Parinari curatellifolia showed MIC 99 of 62.5 and 62.5–125 μg/mL, respectively, on M. bovis BCG”
e4“showed IC 50 values of 28 and 20 μg/mL, respectively suggesting a low selectivity index”
Claim · model-written summary
Methanolic extract of Parinari curatellifolia had MIC 99 of 62.5–125 μg/mL on M. bovis BCG.
- Taxon
- Parinari curatellifolia
.jpg?width=60)
Parinari curatellifoliae3 - Interactor
- M. bovis BCGMycobacterium tuberculosis variant bovise3other
- Outcome
- MIC 99e3
- Value
- 62.5–125e3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
.jpg?width=500)
Verbatim
e3“The methanolic extracts of Zanthoxylum chalybeum and Parinari curatellifolia showed MIC 99 of 62.5 and 62.5–125 μg/mL, respectively, on M. bovis BCG”
Claim · model-written summary
Methanolic extract of Parinari curatellifolia had IC 50 of 20 μg/mL.
- Taxon
- Parinari curatellifoliaParinari curatellifoliae3
- Outcome
- IC 50 valuese4
- Value
- 20e4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e3“The methanolic extracts of Zanthoxylum chalybeum and Parinari curatellifolia showed MIC 99 of 62.5 and 62.5–125 μg/mL, respectively, on M. bovis BCG”
e4“showed IC 50 values of 28 and 20 μg/mL, respectively suggesting a low selectivity index”
Claim · model-written summary
The two best extracts show a low selectivity index.
- Taxon
- Zanthoxylum chalybeum and Parinari curatellifoliaParinari curatellifoliaZanthoxylum chalybeume3
- Outcome
- selectivity indexe4
- Qualifier
- low selectivity indexe4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e3“The methanolic extracts of Zanthoxylum chalybeum and Parinari curatellifolia showed MIC 99 of 62.5 and 62.5–125 μg/mL, respectively, on M. bovis BCG”
e4“showed IC 50 values of 28 and 20 μg/mL, respectively suggesting a low selectivity index”
The same questions in other papers
botanical · growth · Viridiplantae (plants)Positive and negative results
9 papers in the same direction as this paper · 5 in the opposite direction
- negative
- negative
- no effect
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See all 15 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.