By interacting organism › Bacteria › Mycobacteriaceae › Mycobacterium tuberculosis variant bovis

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Methanolic extract of Zanthoxylum chalybeum had MIC 99 of 62.5 μg/mL on M. bovis BCG.

Taxon: Zanthoxylum chalybeumZanthoxylum chalybeume3
Interactor: M. bovis BCGMycobacterium tuberculosis variant bovise3other
Outcome: MIC 99e3
Value: 62.5e3

Verbatim

e3
“The methanolic extracts of Zanthoxylum chalybeum and Parinari curatellifolia showed MIC 99 of 62.5 and 62.5–125 μg/mL, respectively, on M. bovis BCG”
✓ located verbatim in the source · abstract, characters 1375–1523

Title

Ethnobotanical survey and antimycobacterial activities of plants used against tuberculosis in Lubumbashi, DR Congo

Evodie Numbi Wa Ilunga; Marsi Mbayo Kitambala; Kalunga Muya; et al. Tropical Medicine and Health 2025. doi:10.1186/s41182-025-00745-1

Other claims from this paper (6)

Observation Thirty-eight plant species from 23 families were identified in the ethnobotanical survey.
Intervention effect Eleven of 17 plant extracts inhibited the growth of M. smegmatis at MIC 13 to 250 μg/mL.
Observation Methanolic extract of Zanthoxylum chalybeum had IC 50 of 28 μg/mL.
Observation Methanolic extract of Parinari curatellifolia had MIC 99 of 62.5–125 μg/mL on M. bovis BCG.
Observation Methanolic extract of Parinari curatellifolia had IC 50 of 20 μg/mL.
Observation The two best extracts show a low selectivity index.

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Methanolic extract of Parinari curatellifolia had MIC 99 of 62.5–125 μg/mL on M. bovis BCG.

Taxon: Parinari curatellifoliaParinari curatellifoliae3
Interactor: M. bovis BCGMycobacterium tuberculosis variant bovise3other
Outcome: MIC 99e3
Value: 62.5–125e3

Verbatim

e3
“The methanolic extracts of Zanthoxylum chalybeum and Parinari curatellifolia showed MIC 99 of 62.5 and 62.5–125 μg/mL, respectively, on M. bovis BCG”
✓ located verbatim in the source · abstract, characters 1375–1523

Title

Ethnobotanical survey and antimycobacterial activities of plants used against tuberculosis in Lubumbashi, DR Congo

Evodie Numbi Wa Ilunga; Marsi Mbayo Kitambala; Kalunga Muya; et al. Tropical Medicine and Health 2025. doi:10.1186/s41182-025-00745-1

Other claims from this paper (6)

Observation Thirty-eight plant species from 23 families were identified in the ethnobotanical survey.
Intervention effect Eleven of 17 plant extracts inhibited the growth of M. smegmatis at MIC 13 to 250 μg/mL.
Observation Methanolic extract of Zanthoxylum chalybeum had MIC 99 of 62.5 μg/mL on M. bovis BCG.
Observation Methanolic extract of Zanthoxylum chalybeum had IC 50 of 28 μg/mL.
Observation Methanolic extract of Parinari curatellifolia had IC 50 of 20 μg/mL.
Observation The two best extracts show a low selectivity index.

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

The crude extract activity showed a minimum inhibitory concentration as low as 19.5 µg/mL against nonpathogenic M. bovis strains.

Taxon: medicinal plant speciese1
Interactor: M. bovisMycobacterium tuberculosis variant bovise2other
Outcome: Minimum inhibitory concentration valuee2
Value: 19.5µg/mLe2
Qualifier: non-pathogenic strainse2

Verbatim

e1
“all the eight tested medicinal plant species had activity against all the three tested mycobacterial strains”
✓ located verbatim in the source · abstract, characters 1012–1120

e2
“Minimum inhibitory concentration value as low as 19.5µg/mL was observed against non-pathogenic strains M. bovis”
✓ located verbatim in the source · abstract, characters 1122–1233

Title

In vitro antimycobacterial activity and toxicity of eight medicinal plants against pathogenic and nonpathogenic mycobacterial strains.

Nguta, JM; Appiah-Opong, R; Nyarko, AK; et al. DOAJ (DOAJ: Directory of Open Access Journals) 2016

Other claims from this paper (3)

Associationobservedoriginal resultmeasured

Claim · model-written summary

Activity of the crude extracts against M. aurum was the best predictor of activity against pathogenic M. bovis, with R2 of 0.1371.

Taxon: medicinal plantst0
Interactor: Mycobacterium bovisMycobacterium tuberculosis variant bovise3pathogen
Second interactor: M. aurumMycolicibacterium aurume3other
Outcome: best predictor of natural product activitye3
Value: 0.1371e3

Not reportedDirection

Verbatim

t0
“eight medicinal plants”
✓ located verbatim in the source · title, characters 52–74

e3
“Activity of the crude extracts against M. aurum was the best predictor of natural product activity against the pathogenic Mycobacterium bovis strain, with a correlation coefficient value (R2) of 0.1371”
✓ located verbatim in the source · abstract, characters 1235–1436

Title

In vitro antimycobacterial activity and toxicity of eight medicinal plants against pathogenic and nonpathogenic mycobacterial strains.

Nguta, JM; Appiah-Opong, R; Nyarko, AK; et al. DOAJ (DOAJ: Directory of Open Access Journals) 2016

Other claims from this paper (3)

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Arjunolic acid showed the strongest activity against Mycobacterium bovis BCG among the isolated compounds.

Taxon: Terminalia AvicennioidesTerminalia avicennioidest0
Interactor: Mycobacterium bovisMycobacterium tuberculosis variant bovise0other
Outcome: antimycobacterial activitye0
Direction: most potente0

Verbatim

e0
“Among them, arjunolic acid manifested the most potent antimycobacterial activity against a strain of Mycobacterium bovis (BCG).”
✓ located verbatim in the source · abstract, characters 602–729

t0
“Terminalia Avicennioides”
✓ located verbatim in the source · title, characters 86–110

Title

Isolation and Elucidation of Three Triterpenoids and Its Antimycobacterial Activty of Terminalia Avicennioides

Abdullahi Mann; Kolo Ibrahim; Adebayo O. Oyewale; et al. American Journal of Organic Chemistry 2012. doi:10.5923/j.ajoc.20120202.03

Other claims from this paper (1)

Observation Arjunolic acid, α-amyrin and 2, 3, 23-trihydroxylolean-12-ene were isolated from Terminalia avicennioides.

Observationobservedoriginal resultpositivesignificant (as stated)measured

Claim · model-written summary

Compounds 15, 16 and 17 showed potent activity against Mycobacterium strains M. tuberculosis H37Rv and M. bovis BCG.

Taxon: Ferula hermonisFerula hermonise0
Interactor: M. tuberculosis H37RvMycobacterium tuberculosise3other
Second interactor: M. bovis BCGMycobacterium tuberculosis variant bovise3other
Compound: compounds 15, 16, 17e3
Outcome: potent activitye3

Verbatim

e0
“Seventeen daucane sesquiterpenoid esters, including a new one (4), were isolated from the root of Ferula hermonis Boiss”
✓ located verbatim in the source · abstract, characters 0–119

e3
“There was a significant indication that compounds 15, 16, 17 demonstrated potent activity against Gram +ve (S. aureus, B. subtilis), as well as Mycobacterium strains M. bovis BCG and M. tuberculosis H37Rv”
✓ located verbatim in the source · abstract, characters 788–992

Title

Antimicrobial Antioxidant Daucane Sesquiterpenes from Ferula hermonis Boiss

Zedan Zeid Ibraheim; Wael M. Abdel‐Mageed; Huanqin Dai; et al. Phytotherapy Research 2011. doi:10.1002/ptr.3609

Other claims from this paper (6)

Mycobacterium tuberculosis variant bovis 6 claims

6 claims