Abstract
Seed dormancy and germination are dynamically regulated by abscisic acid (ABA), with transcription factor ABA INSENSITIVE 5 (ABI5) serving as a key repressor of germination under stress. Here, we identify QUIRKY (QKY), a MULTIPLE C2 DOMAIN AND TRANSMEMBRANE REGION PROTEIN (MCTP) in Arabidopsis , as a critical regulator of ABA signaling through posttranslational control of ABI5. QKY interacts with ABI5 and facilitates its cytoplasmic degradation via the E3 ubiquitin ligase KEEP ON GOING (KEG), promoting the recruitment of ABI5 into phase-separated condensates. Loss of QKY function enhances ABA hypersensitivity, reducing seed germination rates and impairing seedling establishment. These findings highlight QKY as a scaffold that integrates phase separation and targeted ubiquitination to fine-tune ABA responses, balancing dormancy and germination. Our study expands the understanding of posttranslational ABI5 regulation and reveals MCTPs as central players in coordinating growth-stress trade-offs during early plant development.
Abstract from the paper’s OpenAlex record; open copy licensed cc-by-nc. Read at the source ↗
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Claims 5
Claim · model-written summary
QKY was identified as a regulator of ABA signaling through ABI5 control.
- Taxon
- Arabidopsis
Arabidopsise0 - Gene
- QUIRKY (QKY)e0
- Outcome
- ABA signaling through posttranslational control of ABI5e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“identify QUIRKY (QKY), a MULTIPLE C2 DOMAIN AND TRANSMEMBRANE REGION PROTEIN (MCTP) in Arabidopsis , as a critical regulator of ABA signaling through posttranslational control of ABI5”
Claim · model-written summary
QKY interacts with ABI5 and facilitates KEG-mediated cytoplasmic degradation and condensate recruitment.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- QKYe0
- Outcome
- cytoplasmic degradatione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“QKY interacts with ABI5 and facilitates its cytoplasmic degradation via the E3 ubiquitin ligase KEEP ON GOING (KEG), promoting the recruitment of ABI5 into phase-separated condensates”
t0“in Arabidopsis”
Claim · model-written summary
Loss of QKY enhances ABA hypersensitivity.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- QKYe0
- Outcome
- ABA hypersensitivitye0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Loss of QKY function enhances ABA hypersensitivity”
t0“in Arabidopsis”
Claim · model-written summary
Loss of QKY reduces seed germination rates.
- Taxon
- ArabidopsisArabidopsist0
- Outcome
- seed germination ratese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“reducing seed germination rates and impairing seedling establishment”
t0“in Arabidopsis”
Claim · model-written summary
Loss of QKY impairs seedling establishment.
- Taxon
- ArabidopsisArabidopsist0
- Outcome
- seedling establishmente0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“reducing seed germination rates and impairing seedling establishment”
t0“in Arabidopsis”