Abstract
Celastrus orbiculatus fruits as Beihehuan (BHH) in Chinese are used as an alternative to Albizia julibrissin flowers (Hehuanhua) for insomnia treatment in North of China. Both of them perhaps contain similar material foundations with common components, making them highly worthy of systematic analysis of the ingredients and related pharmacological mechanisms. In this study, the components in BHH were comprehensively analyzed by LC-MS/MS-based molecular networking technology combined with literature reports, and important targets and core active ingredients in BHH that can treat insomnia were screened through network pharmacology and molecular docking analysis. Finally, a total of 136 components were annotated and summarized. BHH had flavonoids, fatty acids, and volatile oil as similar or the same component categories and structures as Hehuanhua, especially different categories of dihydro-β-agarofuran-type sesquiterpenoids with similar functions. The screened top 10 KEGG pathways involved signal transduction related to neurotransmitters, hormones, and addictive substances, and the selected effective ingredients could play synergistic roles in inflammation regulation and neuroprotection. These results provide that BHH may be able to replace Hehuanhua in treating insomnia and other neurological disorders; modern research can provide the scientific connotation and basis for the proposed forward-thinking TCM theory of "effect-oriented source unification" and "heteroagent possessing homofunction."
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Claims 6
Claim · model-written summary
A total of 136 components were annotated in Celastrus orbiculatus fruit (BHH).
- Taxon
- Celastrus orbiculatus
.JPG?width=60)
Celastrus orbiculatuse0 - Outcome
- componentse1
- Value
- 136e1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
.JPG?width=500)
Verbatim
e0“Celastrus orbiculatus fruits as Beihehuan (BHH) in Chinese are used as an alternative to Albizia julibrissin flowers (Hehuanhua)”
e1“a total of 136 components were annotated and summarized”
Claim · model-written summary
Celastrus orbiculatus fruit had flavonoids, fatty acids and volatile oil as component categories similar to or the same as Hehuanhua.
- Taxon
- Celastrus orbiculatusCelastrus orbiculatuse0
- Outcome
- flavonoids, fatty acids, and volatile oile2
- Comparator
- Hehuanhuae2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Celastrus orbiculatus fruits as Beihehuan (BHH) in Chinese are used as an alternative to Albizia julibrissin flowers (Hehuanhua)”
e2“BHH had flavonoids, fatty acids, and volatile oil as similar or the same component categories and structures as Hehuanhua”
Claim · model-written summary
Celastrus orbiculatus fruit contained categories of dihydro-β-agarofuran-type sesquiterpenoids with similar functions to Hehuanhua.
- Taxon
- Celastrus orbiculatusCelastrus orbiculatuse0
- Outcome
- categories of dihydro-β-agarofuran-type sesquiterpenoidse3
- Qualifier
- with similar functionse3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Celastrus orbiculatus fruits as Beihehuan (BHH) in Chinese are used as an alternative to Albizia julibrissin flowers (Hehuanhua)”
e3“especially different categories of dihydro-β-agarofuran-type sesquiterpenoids with similar functions”
Claim · model-written summary
The top 10 KEGG pathways for Celastrus orbiculatus components involved signal transduction related to neurotransmitters, hormones and addictive substances.
- Taxon
- Celastrus orbiculatusCelastrus orbiculatuse0
- Outcome
- top 10 KEGG pathwayse4
- Qualifier
- signal transduction related to neurotransmitters, hormones, and addictive substancese4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Celastrus orbiculatus fruits as Beihehuan (BHH) in Chinese are used as an alternative to Albizia julibrissin flowers (Hehuanhua)”
e4“The screened top 10 KEGG pathways involved signal transduction related to neurotransmitters, hormones, and addictive substances”
Claim · model-written summary
Selected effective ingredients of Celastrus orbiculatus could play synergistic roles in inflammation regulation and neuroprotection.
- Taxon
- Celastrus orbiculatusCelastrus orbiculatuse0
- Outcome
- inflammation regulation and neuroprotectione5
- Qualifier
- synergistic rolese5
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Celastrus orbiculatus fruits as Beihehuan (BHH) in Chinese are used as an alternative to Albizia julibrissin flowers (Hehuanhua)”
e5“the selected effective ingredients could play synergistic roles in inflammation regulation and neuroprotection”
Claim · model-written summary
Celastrus orbiculatus fruit (BHH) may be able to replace Hehuanhua in treating insomnia.
- Taxon
- Celastrus orbiculatusCelastrus orbiculatuse0
- Outcome
- replace Hehuanhua in treating insomniae6
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Celastrus orbiculatus fruits as Beihehuan (BHH) in Chinese are used as an alternative to Albizia julibrissin flowers (Hehuanhua)”
e6“BHH may be able to replace Hehuanhua in treating insomnia and other neurological disorders”