By interacting organism › Bacteria › Rhizobiaceae › Sinorhizobium meliloti

Intervention effectobservedoriginal resultnegativemeasured

Claim · model-written summary

Most host mutations reduced host benefits in Medicago truncatula with Sinorhizobium meliloti.

Taxon: Medicago truncatulaMedicago truncatulae0
Treatment: mutationse1
Interactor: Sinorhizobium melilotiSinorhizobium melilotie0symbiont
Outcome: host benefitse1
Direction: reducede1

Not reportedComparator

Verbatim

e0
“we inoculated 18 Medicago truncatula symbiotic mutants (including mutants that alter Nodule Cysteine-Rich (NCR) peptide production, plant defence, and nodule number regulation) with a mixture of 86 Sinorhizobium meliloti strains”
✓ located verbatim in the source · abstract, characters 346–574

e1
“Most mutations resulted in reduced host benefits, but the effects on rhizobial benefit (i.e. relative strain fitness) varied widely, revealing widespread host-by-strain fitness interactions”
✓ located verbatim in the source · abstract, characters 576–765

Title

Mutations in legume genes that influence symbiosis create a complex selective landscape for rhizobial symbionts

Sohini Guha; Regina B Bledsoe; Jeremy Sutherland; et al. The ISME Journal 2026. doi:10.1093/ismejo/wrag005

Other claims from this paper (10)

Observationobservedoriginal resultmeasured

Claim · model-written summary

Effects of host mutations on relative strain fitness of rhizobia varied widely.

Taxon: Medicago truncatulaMedicago truncatulae0
Interactor: Sinorhizobium melilotiSinorhizobium melilotie0symbiont
Outcome: relative strain fitnesse1
Qualifier: varied widelye1

Verbatim

e0
“we inoculated 18 Medicago truncatula symbiotic mutants (including mutants that alter Nodule Cysteine-Rich (NCR) peptide production, plant defence, and nodule number regulation) with a mixture of 86 Sinorhizobium meliloti strains”
✓ located verbatim in the source · abstract, characters 346–574

e1
“Most mutations resulted in reduced host benefits, but the effects on rhizobial benefit (i.e. relative strain fitness) varied widely, revealing widespread host-by-strain fitness interactions”
✓ located verbatim in the source · abstract, characters 576–765

Title

Mutations in legume genes that influence symbiosis create a complex selective landscape for rhizobial symbionts

Sohini Guha; Regina B Bledsoe; Jeremy Sutherland; et al. The ISME Journal 2026. doi:10.1093/ismejo/wrag005

Other claims from this paper (10)

Associationobservedoriginal resultmeasured

Claim · model-written summary

Genome-wide association variants on rhizobial replicons pSymA and pSymB are important in mediating strain fitness responses to host mutations.

Taxon: Medicago truncatulaMedicago truncatulae0
Treatment: host mutationse2
Interactor: Sinorhizobium melilotiSinorhizobium melilotie0symbiont
Outcome: strain fitness responses to host mutationse2

Not reportedDirection

Verbatim

e0
“we inoculated 18 Medicago truncatula symbiotic mutants (including mutants that alter Nodule Cysteine-Rich (NCR) peptide production, plant defence, and nodule number regulation) with a mixture of 86 Sinorhizobium meliloti strains”
✓ located verbatim in the source · abstract, characters 346–574

e2
“Genome-wide association analyses identified variants on rhizobial replicons pSymA and pSymB as important in mediating strain fitness responses to host mutations”
✓ located verbatim in the source · abstract, characters 767–927

Title

Mutations in legume genes that influence symbiosis create a complex selective landscape for rhizobial symbionts

Sohini Guha; Regina B Bledsoe; Jeremy Sutherland; et al. The ISME Journal 2026. doi:10.1093/ismejo/wrag005

Other claims from this paper (10)

Mechanismhypothesisoriginal resultsimulated

Claim · model-written summary

AlphaFold multimer modelling suggests that many rhizobial top candidates could interact with host NCR peptides.

Taxon: Medicago truncatulaMedicago truncatulae0
Interactor: Sinorhizobium melilotiSinorhizobium melilotie0symbiont
Gene: NCR peptidese7
Outcome: interact with host NCR peptidese7
Qualifier: AlphaFold multimer modelling suggestse7

Verbatim

e0
“we inoculated 18 Medicago truncatula symbiotic mutants (including mutants that alter Nodule Cysteine-Rich (NCR) peptide production, plant defence, and nodule number regulation) with a mixture of 86 Sinorhizobium meliloti strains”
✓ located verbatim in the source · abstract, characters 346–574

e7
“AlphaFold multimer modelling suggests that many rhizobial top candidates could interact with host NCR peptides”
✓ located verbatim in the source · abstract, characters 1515–1625

Title

Mutations in legume genes that influence symbiosis create a complex selective landscape for rhizobial symbionts

Sohini Guha; Regina B Bledsoe; Jeremy Sutherland; et al. The ISME Journal 2026. doi:10.1093/ismejo/wrag005

Other claims from this paper (10)

Observationobservedoriginal resultsignificant (as stated)measured

Claim · model-written summary

Re-analysis of 202 Medicago accessions showed significant genetic variation in the capacity to restrict rhizobial strain diversity.

Taxon: MedicagoMedicagoe1
Material: 202 accessionse1
Interactor: Sinorhizobium melilotiSinorhizobium melilotie0symbiont
Outcome: genetic variation in the capacity of Medicago to restrict strain diversitye1

Verbatim

e0
“We examined these two components using the legume Medicago truncatula and its nitrogen-fixing symbiont Sinorhizobium meliloti”
✓ located verbatim in the source · abstract, characters 128–253

e1
“we re-analysed data from 202 accessions to show significant genetic variation in the capacity of Medicago to restrict strain diversity”
✓ located verbatim in the source · abstract, characters 262–396

Title

Genetic variation in host selectivity and adaptive strain enrichment in legume-rhizobia symbiosis: host-dependent, imperfect processes correlate with nodule morphology

Liana T. Burghardt; Patrick Sydow; Jeremy Sutherland; et al. Proceedings of the Royal Society B Biological Sciences 2026. doi:10.1098/rspb.2025.2851

Other claims from this paper (5)

Method / resourceobservedoriginal resultpositivemeasured

Claim · model-written summary

Among the formulations tested, a mixed alginate–gum Arabic matrix gave the best overall balance of process efficiency, post-drying viability, stability and symbiotic performance

Taxon: alfalfaMedicago sativae2
Treatment: mixed alginate–gum Arabic matrixe1
Interactor: Ensifer melilotiSinorhizobium melilotie0symbiont
Outcome: overall balance between process efficiency, post-drying viability, long-term stability, and symbiotic performancee1
Comparator: the formulations testede1

Verbatim

e0
“using Ensifer meliloti Rm8530”
✓ located verbatim in the source · abstract, characters 374–403

e1
“Among the formulations tested, a mixed alginate–gum Arabic matrix showed the best overall balance between process efficiency, post-drying viability, long-term stability, and symbiotic performance”
✓ located verbatim in the source · abstract, characters 1131–1326

e2
“validated in planta using alfalfa as a host model”
✓ located verbatim in the source · abstract, characters 1080–1129

Title

From Cell Physiology to Process Design: Spray-Drying-Based Production of a Stable and Functional Ensifer meliloti Bioinoculant

Florencia Belén Alvarez Strazzi; María Evangelina Carezzano; Martina Guerrieri Magrini; et al. Processes 2026. doi:10.3390/pr14071094

Other claims from this paper (1)

Observation Spray-dried Ensifer meliloti cells retained the ability to induce nodulation and support early plant responses under the conditions evaluated

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Spray-dried Ensifer meliloti cells retained the ability to induce nodulation and support early plant responses under the conditions evaluated

Taxon: alfalfaMedicago sativae2
Treatment: Spray-dried cellse3
Interactor: Ensifer melilotiSinorhizobium melilotie0symbiont
Outcome: induce nodulation and support early plant responsese3
Qualifier: under the conditions evaluatede3

Verbatim

e0
“using Ensifer meliloti Rm8530”
✓ located verbatim in the source · abstract, characters 374–403

e2
“validated in planta using alfalfa as a host model”
✓ located verbatim in the source · abstract, characters 1080–1129

e3
“Spray-dried cells retained the ability to induce nodulation and support early plant responses under the conditions evaluated”
✓ located verbatim in the source · abstract, characters 1328–1452

Title

From Cell Physiology to Process Design: Spray-Drying-Based Production of a Stable and Functional Ensifer meliloti Bioinoculant

Florencia Belén Alvarez Strazzi; María Evangelina Carezzano; Martina Guerrieri Magrini; et al. Processes 2026. doi:10.3390/pr14071094

Other claims from this paper (1)

Method / resource Among the formulations tested, a mixed alginate–gum Arabic matrix gave the best overall balance of process efficiency, post-drying viability, stability and symbiotic performance

Associationobservedoriginal resultpositivemeasured

Claim · model-written summary

Evidence consistent with nitrogen fixation by S. meliloti was associated with enhanced plant growth and root development.

Taxon: Arabidopsis thalianaArabidopsis thalianat0
Interactor: S. melilotiSinorhizobium melilotie0symbiont
Outcome: plant growth and root system developmente0
Direction: enhancese0

Verbatim

e0
“functional evidence consistent with biological nitrogen fixation from S. meliloti enhances plant growth and root system development”
✓ located verbatim in the source · abstract, characters 445–576

t0
“Arabidopsis thaliana”
✓ located verbatim in the source · title, characters 70–90

Title

NSP1 and NLP9 mediate a beneficial, non-canonical interaction between Arabidopsis thaliana and Sinorhizobium meliloti under nitrogen deficiency

Grace Armijo-Godoy; Isabel Pochet; Tatiana Kraiser; et al. Journal of Experimental Botany 2026. doi:10.1093/jxb/erag005

Other claims from this paper (5)

Observationobservedoriginal resultmeasured

Claim · model-written summary

Microscopy showed bacterial colonization on the root epidermis.

Taxon: Arabidopsis thalianaArabidopsis thalianat0
Organ / stage: root epidermise0
Interactor: Sinorhizobium melilotiSinorhizobium melilotit0symbiont
Outcome: bacterial colonization on the root epidermise0

Verbatim

e0
“Microscopy showed bacterial colonization on the root epidermis”
✓ located verbatim in the source · abstract, characters 723–785

t0
“Arabidopsis thaliana and Sinorhizobium meliloti”
✓ located verbatim in the source · title, characters 70–117

Title

NSP1 and NLP9 mediate a beneficial, non-canonical interaction between Arabidopsis thaliana and Sinorhizobium meliloti under nitrogen deficiency

Grace Armijo-Godoy; Isabel Pochet; Tatiana Kraiser; et al. Journal of Experimental Botany 2026. doi:10.1093/jxb/erag005

Other claims from this paper (5)

Mechanismobservedoriginal resultpositivemeasured

Claim · model-written summary

NSP1 and NLP9 mediated signaling that allowed S. meliloti nitrogenase activity.

Taxon: Arabidopsis thalianaArabidopsis thalianat0
Interactor: S. melilotiSinorhizobium melilotie0symbiont
Gene: NSP1 and NLP9e0
Outcome: S. meliloti's nitrogenase activitye0

Verbatim

e0
“NSP1 and NLP9 as mediators of plant signaling, which modulate the host program to allow S. meliloti's nitrogenase activity”
✓ located verbatim in the source · abstract, characters 822–944

t0
“Arabidopsis thaliana”
✓ located verbatim in the source · title, characters 70–90

Title

NSP1 and NLP9 mediate a beneficial, non-canonical interaction between Arabidopsis thaliana and Sinorhizobium meliloti under nitrogen deficiency

Grace Armijo-Godoy; Isabel Pochet; Tatiana Kraiser; et al. Journal of Experimental Botany 2026. doi:10.1093/jxb/erag005

Other claims from this paper (5)

Sinorhizobium meliloti 3,132 claims

3,132 claims