Intervention effectmodel-written summary

Silencing GLYCOALKALOID METABOLISM 4 prevented SGA accumulation in potato tubers.

A claim from Biosynthesis of Antinutritional Alkaloids in Solanaceous Crops Is Mediated by Clustered Genes · 2013

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Silencing GLYCOALKALOID METABOLISM 4 prevented SGA accumulation in potato tubers.

Organ / stage
tuberse0
Treatment
Silencing GLYCOALKALOID METABOLISM 4e0
Gene
GLYCOALKALOID METABOLISM 4e0
Outcome
accumulation of SGAse0
Direction
preventede0

Not reportedMaterialCompoundInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValueQualifier

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Solanum tuberosum
Solanum tuberosum · TaxonScott Bauer, USDA ARS · Public domain · Wikimedia Commons ↗

Verbatim

e0

“Silencing GLYCOALKALOID METABOLISM 4 prevented accumulation of SGAs in potato tubers and tomato fruit.”

✓ located verbatim in the source · abstract, characters 643–745

Title

Biosynthesis of Antinutritional Alkaloids in Solanaceous Crops Is Mediated by Clustered Genes

M. Itkin; U. Heinig; O. Tzfadia; et al. Science 2013. doi:10.1126/science.1240230

Other claims from this paper (5)

Record rev-18ea5eeffbf885a6fe0bddaca50dcaa7f74e464bdad09b7bb703a04063a79d0d · schema claims-v0.9 · position 5 in the model’s answer

glycoalkaloid · molecular: metabolites · Solanum tuberosum (potato)Positive and negative results

2 papers: 1 positive, 1 negative or no effect

1 in the opposite direction

  1. negative
    Incubation in a glycoalkaloid solution caused a 50% decrease in TTC reduction activity in Atlantic.

    Heat-Induced Damage in Potato (Solanum tuberosum) Tubers:  Membrane Stability, Tissue Viability, and Accumulation of Glycoalkaloids · 1998

    Opposite direction

See all 2 papers →

loss of function · molecular: metabolites · Solanum tuberosum (potato)Positive and negative results

22 papers: 9 positive, 13 negative or no effect

8 papers in the same direction as this claim · 13 in the opposite direction

  1. negative
    Silencing reduced glycerol esterified to suberin by 60%.

    CYP86A33 -Targeted Gene Silencing in Potato Tuber Alters Suberin Composition, Distorts Suberin Lamellae, and Impairs the Periderm's Water Barrier Function    · 2008

    Opposite direction

  2. negative
    Tuber periderm and root exodermis showed reduced suberin staining.

    The ABC Transporter ABCG1 Is Required for Suberin Formation in Potato Tuber Periderm · 2014

    Opposite direction

  3. negative
    Silencing of GBSS required a higher urea concentration for gelatinisation.

    Overexpression of STARCH BRANCHING ENZYME II increases short-chain branching of amylopectin and alters the physicochemical properties of starch from potato tuber · 2015

    Opposite direction

  4. negative
    Small-subunit Lys-404 alanine mutation reduced activator affinity 3090-fold.

    ADP-Glucose Pyrophosphorylase from Potato Tubers. Site-Directed Mutagenesis Studies of the Regulatory Sites1 · 1998

    Opposite direction

  5. no effect
    Antisense inhibition did not noticeably affect tuber sucrose pools.

    Antisense inhibition of cytosolic phosphorylase in potato plants (Solanum tuberosum L.) affects tuber sprouting and flower formation with only little impact on carbohydrate metabolism · 1997

    Opposite direction

  6. negative
    Diminished anionic peroxidase expression in antisense APO plants results in deficient lignin deposition in cell walls.

    Anionic peroxidase‐mediated oxidative burst requirement for jasmonic acid‐dependent Solanum tuberosum defence against Phytophthora infestans · 2017

    Opposite direction

  7. negative
    Silencing StMYB168 and StWRKY20 significantly reduced lignin content in wounded potato tubers.

    MYB168 and WRKY20 transcription factors synergistically regulate lignin monomer synthesis during potato tuber wound healing · 2024

    Opposite direction

  8. negative
    Transformed potato plants accumulated less lignin.

    RNA silencing of the anionic peroxidase gene impairs potato plant resistance to Phytophthora infestans (Mont.) de Bary · 2014

    Opposite direction

13 papers more in this group

See all 22 papers →

Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.