Claim · model-written summary
The glucose analogue 2dog arrested primary root growth in intact seedlings.
Not reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingDirectionValueQualifier
Verbatim
e0“cell death and growth arrest of the primary root in intact seedlings in response to the glucose analogue 2dog”
t0“A. thaliana”
Title
Sugar-modulated gene expression and cell division in cell culture and seedlings of A. thaliana
Sabine Kunz KTH Publication Database DiVA (KTH Royal Institute of Technology) 2014
Other claims from this paper (15)
- Method / resource An A. thaliana cell culture sustained in hormone-free medium was developed with Xyl as its sole carbon source.
- Observation Glucose specifically regulated sugar-responsive candidate genes.
- Observation Fructose specifically regulated sugar-responsive candidate genes.
- Observation Sucrose specifically regulated sugar-responsive candidate genes.
- Mechanism Regulation of bZIP63, AT5g22920 and TPS9 required sugar transport and metabolism.
- Mechanism Regulation of MGD2 and BT2 required sugar transport and metabolism.
- Mechanism Hexokinase 1 catalytic activity was required to regulate bZIP63, Atg22920 and BT2 in seedlings with perturbed carbohydrate balance.
- Mechanism A proposed model assigned bZIP63, AT5g22920 and TPS9 a possible role in cell division.
- Mechanism The proposed model assigned MGD2 and BT2 a possible role in cell division.
- Method / resource An optimized protocol enabled long-term real-time live-cell imaging.
- Observation Cell division progression depended on sugar type at single-cell level.
- Mechanism The sugar-specific cell division response was likely due to prolonged interphase.
- Intervention effect The glucose analogue 2dog caused cell death in intact seedlings.
- Mechanism The authors concluded sugar signals alone sufficed to induce cell division.
- Mechanism Sustained cell-cycle progression and organ growth required sugar energy.