Claim · model-written summary
BSP-2 inhibited the production of IFN-γ, TNF-α and IL-1β in LPS-stimulated RAW264.7 cells.
- Taxon
- B. striata
Bletilla striatae1 - Material
- RAW264.7e7
- Treatment
- BSP-2e7
- Outcome
- IFN-γ, TNF-α, IL-1βe7
- Direction
- inhibitede7
Not reportedGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“isolate and identify a low-molecular-weight polysaccharide (BSP-2) from B. striata tubers”
e7“In LPS-stimulated RAW264.7 cells, BSP-2 inhibited the production of four pro-inflammatory mediators: IFN-γ, TNF-α, IL-1β, and IL-6”
Title
Guofeng Pang; Kai Zhou; Di Gao; et al. Frontiers in Immunology 2026. doi:10.3389/fimmu.2026.1749545
Other claims from this paper (8)
- Observation BSP-2 was dominated by glucose, with minor galactose, arabinose and rhamnose residues.
- Observation The number-average molecular weight of BSP-2 was 3.612 ± 0.13646 kDa.
- Observation The weight-average molecular weight of BSP-2 was 4.456 ± 0.18019 kDa.
- Observation The z-average molecular weight of BSP-2 was 6.364 ± 0.5518 kDa.
- Observation The peaked molecular weight of BSP-2 was 2.808 ± 0.09041 kDa.
- Intervention effect BSP-2 inhibited the production of IL-6 in LPS-stimulated RAW264.7 cells.
- Mechanism The anti-inflammatory effects of BSP-2 are mediated by regulation of the NF-κβ pathway.
- Intervention effect BSP-2 downregulated p65, p-p65, IκBα, p-IκBα, COX-2 and iNOS proteins in RAW264.7 cells.