Claim · model-written summary
BSP-2 downregulated p65, p-p65, IκBα, p-IκBα, COX-2 and iNOS proteins in RAW264.7 cells.
- Taxon
- B. striata
Bletilla striatae1 - Treatment
- BSP-2e2
- Outcome
- proteins including p65, p-p65, IκBα, p-IκBα, COX-2, and iNOSe2
- Direction
- downregulatione2
Not reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“isolate and identify a low-molecular-weight polysaccharide (BSP-2) from B. striata tubers”
e2“Mechanistically, the anti-inflammatory effects of BSP-2 were mediated by the regulation of the NF-κβ pathway, which involved the downregulation of proteins including p65, p-p65, IκBα, p-IκBα, COX-2, and iNOS”
Title
Guofeng Pang; Kai Zhou; Di Gao; et al. Frontiers in Immunology 2026. doi:10.3389/fimmu.2026.1749545
Other claims from this paper (8)
- Observation BSP-2 was dominated by glucose, with minor galactose, arabinose and rhamnose residues.
- Observation The number-average molecular weight of BSP-2 was 3.612 ± 0.13646 kDa.
- Observation The weight-average molecular weight of BSP-2 was 4.456 ± 0.18019 kDa.
- Observation The z-average molecular weight of BSP-2 was 6.364 ± 0.5518 kDa.
- Observation The peaked molecular weight of BSP-2 was 2.808 ± 0.09041 kDa.
- Intervention effect BSP-2 inhibited the production of IFN-γ, TNF-α and IL-1β in LPS-stimulated RAW264.7 cells.
- Intervention effect BSP-2 inhibited the production of IL-6 in LPS-stimulated RAW264.7 cells.
- Mechanism The anti-inflammatory effects of BSP-2 are mediated by regulation of the NF-κβ pathway.