Claim · model-written summary
The authors infer protein conformation changes control exchange-factor membrane association and ARF activation.
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianae1 - Outcome
- membrane association of the exchange factor and, thus, activation of ARFse0
- Qualifier
- regulated changes in protein conformatione0
Not reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValue
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“regulated changes in protein conformation control membrane association of the exchange factor and, thus, activation of ARFs”
t0“Arabidopsis”
e1“The GNOM protein plays a fundamental role in Arabidopsis thaliana development”
Title
Nadine Anders; Michael Nielsen; Jutta Keicher; et al. The Plant Cell 2008. doi:10.1105/tpc.107.056515
Other claims from this paper (4)
- Observation A GNOM N-terminal domain mediates dimerization.
- Observation The GNOM N-terminal domain interacts heterotypically with two other conserved domains in vivo.
- Intervention effect Mutations that abolish heterotypic interaction inactivate GNOM.
- Intervention effect Mutations that abolish heterotypic interaction compromise GNOM membrane association.