Claim · model-written summary
Mutations that abolish heterotypic interaction inactivate GNOM.
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianae1 - Treatment
- mutations abolishing this interactione0
- Gene
- GNOMe0
- Outcome
- GNOM proteine0
- Direction
- inactivatee0
Not reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“mutations abolishing this interaction inactivate the GNOM protein”
t0“Arabidopsis”
e1“The GNOM protein plays a fundamental role in Arabidopsis thaliana development”
Title
Nadine Anders; Michael Nielsen; Jutta Keicher; et al. The Plant Cell 2008. doi:10.1105/tpc.107.056515
Other claims from this paper (4)
- Observation A GNOM N-terminal domain mediates dimerization.
- Observation The GNOM N-terminal domain interacts heterotypically with two other conserved domains in vivo.
- Intervention effect Mutations that abolish heterotypic interaction compromise GNOM membrane association.
- Mechanism The authors infer protein conformation changes control exchange-factor membrane association and ARF activation.