Intervention effectmodel-written summary

NRL1 silencing reduced P. infestans colonization.

A claim from Potato NPH3/RPT2-Like Protein StNRL1, Targeted by a Phytophthora infestans RXLR Effector, Is a Susceptibility Factor · 2016

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

NRL1 silencing reduced P. infestans colonization.

Taxon: N. benthamianaNicotiana benthamianae0
Treatment: Virus-induced gene silencing of NRL1e0
Interactor: P. infestansPhytophthora infestanse0pathogen
Gene: NRL1e0
Outcome: P. infestans colonizatione0
Direction: reducede0

Not reportedMaterialCompoundOrgan / stageSecond interactorSecond interactor roleComparatorSettingValueQualifier

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

*Nicotiana benthamiana* · TaxonCharles Andres · CC BY-SA 3.0 · Wikimedia Commons ↗

*Phytophthora infestans* · InteractorHoward F. Schwartz, Colorado State University, United States · CC BY 3.0 us · Wikimedia Commons ↗

Verbatim

e0
“Virus-induced gene silencing of NRL1 in N. benthamiana resulted in reduced P. infestans colonization”
✓ located verbatim in the source · abstract, characters 1071–1171

Title

Potato NPH3/RPT2-Like Protein StNRL1, Targeted by a Phytophthora infestans RXLR Effector, Is a Susceptibility Factor

Lina Yang; Hazel McLellan; Shaista Naqvi; et al. PLANT PHYSIOLOGY 2016. doi:10.1104/pp.16.00178

Other claims from this paper (10)

Intervention effect Pi02860 expression increased P. infestans leaf colonization in Nicotiana benthamiana.
Intervention effect Pi02860 expression increased pathogen colonization in potato.
Intervention effect Pi02860 attenuated INF1-triggered cell death.
Intervention effect Pi02860 did not attenuate Cf4/Avr4-triggered cell death.
Observation Pi02860 interacted with potato NRL1 in yeast and plant assays.
Intervention effect NRL1 silencing accelerated INF1-mediated cell death.
Intervention effect NRL1 silencing did not affect Avr3a suppression of INF1-mediated cell death.
Intervention effect NRL1 silencing significantly attenuated Pi02860 suppression of INF1 cell death.
Intervention effect NRL1 overexpression suppressed INF1-mediated cell death.
Intervention effect NRL1 overexpression increased P. infestans leaf colonization.

Record rev-c8f2e025cae5120f4a41347fac3d6548deadb7a963d989481ae592933a0deb72 · schema claims-v0.9 · position 6 in the model’s answer

loss of function · Phytophthora infestans · Nicotiana benthamianaPositive and negative results

28 papers: 7 positive, 21 negative or no effect

6 papers in the same direction as this claim · 21 in the opposite direction

negative
Silencing NTP1 in Nicotiana benthamiana increases susceptibility to P. infestans.
An RxLR Effector from Phytophthora infestans Prevents Re-localisation of Two Plant NAC Transcription Factors from the Endoplasmic Reticulum to the Nucleus · 2013
Opposite directionCited by this paper
negative
Expression of PexRD2 or silencing of MAPKKKε in Nicotiana benthamiana enhanced susceptibility to P. infestans.
Phytophthora infestans RXLR Effector PexRD2 Interacts with Host MAPKKKε to Suppress Plant Immune Signaling · 2014
Opposite directionCited by this paper
negative
Silencing NbPUB17 in Nicotiana benthamiana by VIGS enhanced P. infestans leaf colonization
U-box E3 ubiquitin ligase PUB17 acts in the nucleus to promote specific immune pathways triggered by Phytophthora infestans · 2015
Opposite directionCited by this paper
negative
Silencing NbMAP3Kβ2 enhanced P. infestans colonization.
Phytophthora infestans RXLR Effectors Target Parallel Steps in an Immune Signal Transduction Pathway · 2019
Opposite directionCites this paper
positive
CHL1 silencing reduced P. infestans colonization on Nicotiana benthamiana.
RXLR Effector AVR2 Up-Regulates a Brassinosteroid-Responsive bHLH Transcription Factor to Suppress Immunity · 2017
Same directionCites this paper
positive
VIK silencing attenuated P. infestans colonization in Nicotiana benthamiana.
The Potato MAP3K StVIK Is Required for the Phytophthora infestans RXLR Effector Pi17316 to Promote Disease · 2018
Same directionCites this paper
positive
NbKNOX3 silencing reduced P. infestans colonization of Nicotiana benthamiana.
A Phytophthora effector promotes homodimerization of host transcription factor StKNOX3 to enhance susceptibility · 2022
Same directionCites this paper
no effect
NOA1 silencing did not increase susceptibility to P. infestans.
MAPK Signaling Regulates Nitric Oxide and NADPH Oxidase-Dependent Oxidative Bursts inNicotiana benthamiana · 2008
Opposite direction

19 papers more in this group

See all 28 papers →

Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.

Functional evidence on NRL1

Claims that state a gain or loss of function of this gene and what it did to a trait, compared with wild type or a control.

NRL1

Nicotiana benthamiana1 paper · 1 traitTested in one paper only

Only one paper in the store tests this gene's function in Nicotiana benthamiana.

Disease resistance1 paper

Restrains
NRL1 silencing reduced P. infestans colonization.
Potato NPH3/RPT2-Like Protein StNRL1, Targeted by a Phytophthora infestans RXLR Effector, Is a Susceptibility Factor · 2016
loss of function → more of the traitThis claim

The program reads each claim's manipulation and the direction of the trait, and from them the gene's role (gain and more, or loss and less, means it promotes the trait). Roles are read by program from each claim's wording. Pairs of papers on the same host, gene and trait were checked claim by claim by two model readers; a pair is marked checked only when both accept it. Gene layer v0.8, 21 trait classes.

Other papers on the same question

loss of function · Phytophthora infestans · Nicotiana benthamianaPositive and negative results

Functional evidence on NRL1

Nicotiana benthamiana1 paper · 1 traitTested in one paper only

Disease resistance1 paper