Intervention effectmodel-written summary

VIK silencing attenuated P. infestans colonization in Nicotiana benthamiana.

A claim from The Potato MAP3K StVIK Is Required for the Phytophthora infestans RXLR Effector Pi17316 to Promote Disease · 2018

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

VIK silencing attenuated P. infestans colonization in Nicotiana benthamiana.

Taxon: N. benthamianaNicotiana benthamianae0
Treatment: Virus-induced gene silencing of VIKe0
Interactor: P. infestansPhytophthora infestanse0pathogen
Gene: VIKe0
Outcome: P. infestans colonizatione0
Direction: attenuatede0

Not reportedMaterialCompoundOrgan / stageSecond interactorSecond interactor roleComparatorSettingValueQualifier

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

*Nicotiana benthamiana* · TaxonCharles Andres · CC BY-SA 3.0 · Wikimedia Commons ↗

*Phytophthora infestans* · InteractorHoward F. Schwartz, Colorado State University, United States · CC BY 3.0 us · Wikimedia Commons ↗

Verbatim

e0
“Virus-induced gene silencing of VIK in N. benthamiana attenuated P. infestans colonization”
✓ located verbatim in the source · abstract, characters 1147–1237

Title

The Potato MAP3K StVIK Is Required for the Phytophthora infestans RXLR Effector Pi17316 to Promote Disease

Fraser Murphy; Qin He; Miles Armstrong; et al. PLANT PHYSIOLOGY 2018. doi:10.1104/pp.18.00028

Other claims from this paper (9)

Intervention effect Pi17316 expression enhanced Phytophthora infestans leaf colonization in potato and Nicotiana.
Intervention effect Pi17316 attenuated INF1-triggered cell death.
Intervention effect Pi17316 did not attenuate cell death triggered by resistance proteins.
Observation Pi17316 directly interacted with StVIK in yeast two-hybrid assays.
Observation The Pi17316–StVIK interaction was confirmed in planta at the plasma membrane.
Intervention effect StVIK overexpression enhanced P. infestans colonization.
Intervention effect VIK overexpression attenuated INF1-triggered cell death.
Intervention effect VIK silencing significantly compromised Pi17316 enhancement of colonization.
Intervention effect VIK silencing significantly compromised Pi17316 suppression of ICD.

Record rev-6594eeb73fd0e04b5b30666350e9baae5bd6eb35d5bb2928a766a7107709b122 · schema claims-v0.9 · position 6 in the model’s answer

loss of function · Phytophthora infestans · Nicotiana benthamianaPositive and negative results

28 papers: 7 positive, 21 negative or no effect

6 papers in the same direction as this claim · 21 in the opposite direction

no effect
NOA1 silencing did not increase susceptibility to P. infestans.
MAPK Signaling Regulates Nitric Oxide and NADPH Oxidase-Dependent Oxidative Bursts inNicotiana benthamiana · 2008
Opposite directionCited by this paper
negative
Silencing NTP1 in Nicotiana benthamiana increases susceptibility to P. infestans.
An RxLR Effector from Phytophthora infestans Prevents Re-localisation of Two Plant NAC Transcription Factors from the Endoplasmic Reticulum to the Nucleus · 2013
Opposite directionCited by this paper
negative
Silencing NbSerk3 markedly enhanced N. benthamiana susceptibility to P. infestans infection.
The Receptor-Like Kinase SERK3/BAK1 Is Required for Basal Resistance against the Late Blight Pathogen Phytophthora infestans in Nicotiana benthamiana · 2011
Opposite directionCited by this paper
negative
Expression of PexRD2 or silencing of MAPKKKε in Nicotiana benthamiana enhanced susceptibility to P. infestans.
Phytophthora infestans RXLR Effector PexRD2 Interacts with Host MAPKKKε to Suppress Plant Immune Signaling · 2014
Opposite directionCited by this paper
negative
Silencing NbPUB17 in Nicotiana benthamiana by VIGS enhanced P. infestans leaf colonization
U-box E3 ubiquitin ligase PUB17 acts in the nucleus to promote specific immune pathways triggered by Phytophthora infestans · 2015
Opposite directionCited by this paper
negative
Silencing NbMAP3Kβ2 enhanced P. infestans colonization.
Phytophthora infestans RXLR Effectors Target Parallel Steps in an Immune Signal Transduction Pathway · 2019
Opposite directionCites this paper
negative
Silencing NbBBX27 in Nicotiana benthamiana increased P. infestans colonization.
Phytophthora RxLR effector Pi18609 suppresses host immunity by promoting turnover of a positive immune regulator StBBX27 · 2025
Opposite directionCites this paper
positive
NRL1 silencing reduced P. infestans colonization.
Potato NPH3/RPT2-Like Protein StNRL1, Targeted by a Phytophthora infestans RXLR Effector, Is a Susceptibility Factor · 2016
Same directionCited by this paper

19 papers more in this group

See all 28 papers →

Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.

Functional evidence on VIK

Claims that state a gain or loss of function of this gene and what it did to a trait, compared with wild type or a control.

VIK

Nicotiana benthamiana1 paper · 1 traitTested in one paper only

Only one paper in the store tests this gene's function in Nicotiana benthamiana.

Disease resistance1 paper

Restrains
VIK silencing attenuated P. infestans colonization in Nicotiana benthamiana.
The Potato MAP3K StVIK Is Required for the Phytophthora infestans RXLR Effector Pi17316 to Promote Disease · 2018
loss of function → more of the traitThis claim

The program reads each claim's manipulation and the direction of the trait, and from them the gene's role (gain and more, or loss and less, means it promotes the trait). Roles are read by program from each claim's wording. Pairs of papers on the same host, gene and trait were checked claim by claim by two model readers; a pair is marked checked only when both accept it. Gene layer v0.8, 21 trait classes.

Other papers on the same question

loss of function · Phytophthora infestans · Nicotiana benthamianaPositive and negative results

Functional evidence on VIK

Nicotiana benthamiana1 paper · 1 traitTested in one paper only

Disease resistance1 paper