Claim · model-written summary
TF suppressed phosphorylated JAK1 and STAT3 expression in rats with chronic prostatitis.
- Taxon
- Hosta plantaginea
Hosta plantagineae0 - Treatment
- TF (25 and 100 mg/kg, p.o.)e3
- Gene
- just another kinase 1 (JAK1)e4
- Outcome
- phosphorylated protein expressionse7
- Direction
- suppressede7
- Qualifier
- signal transducer and activator of transcription 3 (STAT3)e4
Not reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValue
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Hosta plantaginea (Lam.) Aschers flowers (HPF) are well-known for their high flavonoid content”
e3“Efficacy of TF (25 and 100 mg/kg, p.o.) on CP was evaluated in prostate antigen emulsion-induced autoimmune CP rat model”
e7“suppressed phosphorylated protein expressions of nuclear factor kappa-B (NF-κB) p65, inhibitor of NF-κB alpha (IκBα), c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (Erk)”
e4“just another kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3)”
Title
Li Yang; Fengxiang Zhang; Weiwei He; et al. Journal of Ethnopharmacology 2023. doi:10.1016/j.jep.2023.116922
Other claims from this paper (11)
- Method / resource Optimized extraction of total flavonoids from Hosta plantaginea flowers gave an extraction ratio of 65.98 ± 2.14%.
- Observation Fifteen major flavonoids were characterized in the total flavonoid extract of Hosta plantaginea flowers.
- Intervention effect TF (25 and 100 mg/kg, p.o.) reduced prostatic index and leukocyte levels in rats with chronic prostatitis.
- Intervention effect TF (25 and 100 mg/kg, p.o.) elevated lecithin body levels in rats with chronic prostatitis.
- Intervention effect TF (25 and 100 mg/kg, p.o.) ameliorated histopathological damage to the prostate in rats.
- Intervention effect TF suppressed phosphorylated NF-κB p65 and IκBα expression in rats with chronic prostatitis.
- Intervention effect TF suppressed phosphorylated JNK, p38 MAPK and Erk expression in rats with chronic prostatitis.
- Intervention effect TF suppressed phosphorylated PI3K and Akt expression in rats with chronic prostatitis.
- Observation TF inhibited DPPH radicals with an IC50 of 2.02 mg/mL.
- Observation TF inhibited ABTS radicals with an IC50 of 1.79 mg/mL.
- Observation TF inhibited COX-2 with an IC50 of 0.0838 mg/mL.