Abstract
ABS>When whole plants or leaves of Graptopetalum paraguayense are exposed to high dosages of gamma radiation, small protuberances appear on the surface of leaves after some 5 to 6 weeks. Upon histological examination it appears that new, tumor-like growth centers are the cause of these protuberances, which are distributed more or less at random throughout the tissues and apparently are self-limiting in size. At maturity these tumors consist of a dead central region surrounded by several rows of small cells. This complex is usually surrounded by a region of cell enlargement which extends into the originally normal mesophyll tissue. The number of tumors per leaf reached an average maximum of about ten in two different experiments. Since they can be counted with ease in intact leaves and metastases do not occur, quantitative data can be obtained readily. It is suggested that the system described might be useful as an assay for tumor initiation by chemical as well as by physical agents. (auth)
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Claims 7
Claim · model-written summary
High gamma radiation doses induced small protuberances on Graptopetalum leaves after about 5 to 6 weeks.
- Taxon
- Graptopetalum paraguayense
Graptopetalum paraguayensee0 - Organ / stage
- leavese0
- Treatment
- high dosages of gamma radiatione0
- Outcome
- small protuberances appear on the surface of leavese0
- Qualifier
- after some 5 to 6 weekse0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_Graptopetalum_paraguayense_-_leaves.jpg?width=500)
Verbatim
e0“When whole plants or leaves of Graptopetalum paraguayense are exposed to high dosages of gamma radiation, small protuberances appear on the surface of leaves after some 5 to 6 weeks”
Claim · model-written summary
Histology indicated new tumor-like growth centers causing the protuberances.
- Taxon
- Graptopetalum paraguayense
Graptopetalum paraguayensee1 - Outcome
- protuberancese0
- Qualifier
- new, tumor-like growth centerse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_Graptopetalum_paraguayense_-_leaves.jpg?width=500)
Verbatim
e0“new, tumor-like growth centers are the cause of these protuberances”
e1“Graptopetalum paraguayense”
Claim · model-written summary
The growth centers were distributed roughly at random and appeared self-limited in size.
- Taxon
- Graptopetalum paraguayense
Graptopetalum paraguayenset0 - Outcome
- self-limiting in sizee0
- Qualifier
- more or less at random throughout the tissuese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_Graptopetalum_paraguayense_-_leaves.jpg?width=500)
Verbatim
e0“distributed more or less at random throughout the tissues and apparently are self-limiting in size”
t0“Graptopetalum paraguayense”
Claim · model-written summary
Mature tumors had a dead central region surrounded by rows of small cells.
- Taxon
- Graptopetalum paraguayense
Graptopetalum paraguayenset0 - Organ / stage
- At maturitye0
- Outcome
- dead central region surrounded by several rows of small cellse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_Graptopetalum_paraguayense_-_leaves.jpg?width=500)
Verbatim
e0“At maturity these tumors consist of a dead central region surrounded by several rows of small cells”
t0“Graptopetalum paraguayense”
Claim · model-written summary
A region of cell enlargement commonly surrounded tumors and extended into normal mesophyll.
- Taxon
- Graptopetalum paraguayense
Graptopetalum paraguayenset0 - Organ / stage
- mesophyll tissuee0
- Outcome
- region of cell enlargemente0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_Graptopetalum_paraguayense_-_leaves.jpg?width=500)
Verbatim
e0“This complex is usually surrounded by a region of cell enlargement which extends into the originally normal mesophyll tissue”
t0“Graptopetalum paraguayense”
Claim · model-written summary
The number of tumors per leaf averaged a maximum of about ten in two experiments.
- Taxon
- Graptopetalum paraguayense
Graptopetalum paraguayenset0 - Outcome
- number of tumors per leafe0
- Direction
- maximume0
- Value
- about tene0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_Graptopetalum_paraguayense_-_leaves.jpg?width=500)
Verbatim
e0“The number of tumors per leaf reached an average maximum of about ten in two different experiments”
t0“Graptopetalum paraguayense”
Claim · model-written summary
The authors suggest the leaf-tumor system could assay tumor initiation by chemical and physical agents.
- Taxon
- Graptopetalum paraguayense
Graptopetalum paraguayenset0 - Outcome
- assay for tumor initiation by chemical as well as by physical agentse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_Graptopetalum_paraguayense_-_leaves.jpg?width=500)
Verbatim
e0“the system described might be useful as an assay for tumor initiation by chemical as well as by physical agents”
t0“Graptopetalum paraguayense”