Abstract
The Fusarium genus of fungi is responsible for commercially devastating crop diseases and the contamination of cereals with harmful mycotoxins. Fusarium mycotoxins aid infection, establishment, and spread of the fungus within the host plant. We investigated the effects of the Fusarium mycotoxin deoxynivalenol (DON) on the viability of Arabidopsis cells. Although it is known to trigger apoptosis in animal cells, DON treatment at low concentrations surprisingly did not kill these cells. On the contrary, we found that DON inhibited apoptosis-like programmed cell death (PCD) in Arabidopsis cells subjected to abiotic stress treatment in a manner independent of mitochondrial cytochrome c release. This suggested that Fusarium may utilise mycotoxins to suppress plant apoptosis-like PCD. To test this, we infected Arabidopsis cells with a wild type and a DON-minus mutant strain of F. graminearum and found that only the DON producing strain could inhibit death induced by heat treatment. These results indicate that mycotoxins may be capable of disarming plant apoptosis-like PCD and thereby suggest a novel way that some fungi can influence plant cell fate.
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Claims 3
Claim · model-written summary
Low concentrations of DON did not kill Arabidopsis cells.
- Taxon
- Arabidopsis
Arabidopsise1 - Treatment
- DON treatment at low concentrationse0
- Outcome
- viabilitye1
- Direction
- did not kille0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“DON treatment at low concentrations surprisingly did not kill these cells”
e1“viability of Arabidopsis cells”
Claim · model-written summary
DON inhibited abiotic-stress-induced apoptosis-like programmed cell death in Arabidopsis cells independently of mitochondrial cytochrome c release.
- Taxon
- ArabidopsisArabidopsise0
- Treatment
- DONe0
- Outcome
- apoptosis-like programmed cell death (PCD)e0
- Direction
- inhibitede0
- Qualifier
- independent of mitochondrial cytochrome c releasee0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“DON inhibited apoptosis-like programmed cell death (PCD) in Arabidopsis cells subjected to abiotic stress treatment in a manner independent of mitochondrial cytochrome c release”
Claim · model-written summary
Only the DON-producing F. graminearum strain inhibited heat-induced death of Arabidopsis cells compared with the DON-minus mutant.
- Taxon
- ArabidopsisArabidopsise0
- Treatment
- DON producing straine0
- Interactor
- F. graminearum
_on_Corn_(Zea_mays)_at_Waimea%2C_Hawaii.jpg?width=60)
Fusarium graminearume0pathogen - Outcome
- death induced by heat treatmente0
- Direction
- inhibite0
- Comparator
- DON-minus mutant straine0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_on_Corn_(Zea_mays)_at_Waimea%2C_Hawaii.jpg?width=500)
Verbatim
e0“infected Arabidopsis cells with a wild type and a DON-minus mutant strain of F. graminearum and found that only the DON producing strain could inhibit death induced by heat treatment”
The same questions in other papers
deoxynivalenol · cytology · ArabidopsisResults agree
1 paper in the same direction as this paper
- no effect
Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.