Abstract
Gamma-aminobutyric acid( GABA) is a four-carbon non-protein amino acid conserved from bacteria to plants and vertebrates. Increasing evidence supports a regulatory role for GABA in plant development and the plant’s response to environmental stress. The biosynthesis of nicotine,the main economically important metabolite in tobacco,is tightly regulated. GABA has not hitherto been reported to function in nicotine biosynthesis. Here we found that water flooding treatment( hypoxia) markedly induced the accumulation of GABA and stimulated nicotine biosynthesis. Suppressing GABA accumulation by treatment with glutamate decarboxylase inhibitor impaired flooding-induced nicotine biosynthesis,while exogenous GABA application directly induced nicotine biosynthesis. Based on these results,we propose that GABA triggers nicotine biosynthesis in tobacco seedlings subjected to flooding. Our results provide insight into the molecular mechanism of nicotine biosynthesis in tobacco plants exposed to environmental stress.
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Claims 5
Claim · model-written summary
Flooding markedly increased GABA accumulation.
- Taxon
- tobacco
Nicotiana tabacumt0 - Treatment
- water flooding treatment( hypoxia)e0
- Outcome
- accumulation of GABAe0
- Direction
- inducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“water flooding treatment( hypoxia) markedly induced the accumulation of GABA”
t0“tobacco”
Claim · model-written summary
Flooding stimulated nicotine biosynthesis.
- Taxon
- tobaccoNicotiana tabacumt0
- Treatment
- water flooding treatment( hypoxia)e0
- Outcome
- nicotine biosynthesise0
- Direction
- stimulatede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“water flooding treatment( hypoxia) markedly induced the accumulation of GABA and stimulated nicotine biosynthesis”
t0“tobacco”
Claim · model-written summary
Inhibiting GABA accumulation impaired flooding-induced nicotine biosynthesis.
- Taxon
- tobaccoNicotiana tabacumt0
- Treatment
- glutamate decarboxylase inhibitore0
- Compound
- GABAe0
- Outcome
- flooding-induced nicotine biosynthesise0
- Direction
- impairede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Suppressing GABA accumulation by treatment with glutamate decarboxylase inhibitor impaired flooding-induced nicotine biosynthesis”
t0“tobacco”
Claim · model-written summary
Exogenous GABA induced nicotine biosynthesis.
- Taxon
- tobaccoNicotiana tabacumt0
- Treatment
- exogenous GABA applicatione0
- Outcome
- nicotine biosynthesise0
- Direction
- inducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“exogenous GABA application directly induced nicotine biosynthesis”
t0“tobacco”
Claim · model-written summary
The authors propose that GABA triggers nicotine biosynthesis under flooding.
- Taxon
- tobaccoNicotiana tabacume0
- Organ / stage
- seedlingse0
- Compound
- GABAe0
- Outcome
- nicotine biosynthesise0
- Qualifier
- subjected to floodinge0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“we propose that GABA triggers nicotine biosynthesis in tobacco seedlings subjected to flooding”
The same questions in other papers
gamma-aminobutyric acid · molecular: metabolites · Nicotiana tabacum (tobacco)Results agree
1 paper in the same direction as this paper
- positive
EC 4.1.1.15 (glutamate decarboxylase) inhibitor · molecular: metabolites · Nicotiana tabacum (tobacco)Results agree
1 paper in the same direction as this paper
- negative
flooding · molecular: metabolites · Nicotiana tabacum (tobacco)Positive and negative results
1 paper in the same direction as this paper · 6 in the opposite direction
- negative
- no effect
- negative
4 papers more in this group
See all 8 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.