Abstract
In this study, the cytotoxic and antiproliferative effects of Thlaspi perfoliatum methanol extract on human breast cancer cell line (MCF-7) and its genotoxic and mitotic repair effects on Allium cepa root cells against toxic substance (CuSO₄) were evaluated in detail. MTT assay results revealed that the extract significantly reduced the viability of MCF-7 cells and inhibited cell proliferation, particularly at medium and high concentrations (400–1000 ppm). The LD₅₀ value ranging between 400–600 ppm indicates that the extract has a strong antiproliferative effect on cancer cells. On the other hand, analyses conducted on the A. cepa model revealed that the CuSO₄-induced decrease in the mitotic index recovered significantly at low and medium doses, while chromosomal abnormalities decreased depending on the dose and application time. These findings demonstrate that T. perfoliatum exhibits anticancer effects and supports cellular repair processes by protecting genetic material thanks to its bioactive components. In this context, T. perfoliatum methanol extract has the potential to be evaluated as a natural therapeutic agent in the future and contributes to supporting its traditional uses with scientific foundations
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Claims 5
Claim · model-written summary
The methanol extract significantly reduced the viability of MCF-7 cells.
- Taxon
- Thlaspi perfoliatum
Microthlaspi perfoliatume1 - Treatment
- methanol extracte1
- Outcome
- viability of MCF-7 cellse0
- Direction
- reducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“MTT assay results revealed that the extract significantly reduced the viability of MCF-7 cells and inhibited cell proliferation, particularly at medium and high concentrations (400–1000 ppm)”
e1“Thlaspi perfoliatum methanol extract on human breast cancer cell line (MCF-7)”
Claim · model-written summary
The methanol extract inhibited proliferation of MCF-7 cells, particularly at medium and high concentrations (400–1000 ppm).
- Taxon
- Thlaspi perfoliatumMicrothlaspi perfoliatume1
- Treatment
- methanol extracte1
- Outcome
- cell proliferatione0
- Direction
- inhibitede0
- Qualifier
- particularly at medium and high concentrations (400–1000 ppm)e0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“MTT assay results revealed that the extract significantly reduced the viability of MCF-7 cells and inhibited cell proliferation, particularly at medium and high concentrations (400–1000 ppm)”
e1“Thlaspi perfoliatum methanol extract on human breast cancer cell line (MCF-7)”
Claim · model-written summary
The LD50 value of the extract was 400–600 ppm, indicating a strong antiproliferative effect on cancer cells.
- Taxon
- Thlaspi perfoliatumMicrothlaspi perfoliatume1
- Outcome
- LD₅₀ valuee2
- Value
- 400–600 ppme2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Thlaspi perfoliatum methanol extract on human breast cancer cell line (MCF-7)”
e2“The LD₅₀ value ranging between 400–600 ppm indicates that the extract has a strong antiproliferative effect on cancer cells”
Claim · model-written summary
In Allium cepa root cells, the CuSO4-induced decrease in mitotic index recovered significantly at low and medium doses.
- Taxon
- Allium cepa
Allium cepae3 - Organ / stage
- root cellse3
- Treatment
- low and medium dosese4
- Outcome
- mitotic indexe4
- Direction
- recoverede4
- Qualifier
- CuSO₄-inducede4
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e3“Allium cepa root cells against toxic substance (CuSO₄)”
e4“the CuSO₄-induced decrease in the mitotic index recovered significantly at low and medium doses”
Claim · model-written summary
In the A. cepa model, chromosomal abnormalities decreased depending on the dose and application time.
- Taxon
- A. cepaAllium cepae5
- Treatment
- dose and application timee6
- Outcome
- chromosomal abnormalitiese6
- Direction
- decreasede6
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e5“analyses conducted on the A. cepa model”
e6“chromosomal abnormalities decreased depending on the dose and application time”
The same questions in other papers
in vitro · cytology · Allium cepa (onion)Positive and negative results
1 paper in the same direction as this paper · 5 in the opposite direction
- negative
- no effect
- negative
3 papers more in this group
See all 7 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.