Abstract
Cornus mas L. is traditionally used for various medicinal purposes, although systematic data on its pharmacognostic properties are still limited. Considerable variation was observed among plant organs, so phenolic and flavonoid content varied by plant part, with location-related differences among samples, with the highest in leaf and fruit from Bijeljina and the lowest in leaf from Sarajevo. Antioxidant activity was much better in leaf and bark than in fruit. Extracts inhibited ESBL-producing Escherichia coli, with MICs mainly at 125 µg/mL; bark extract (Tuzla) showed 250 µg/mL and reduced biofilm formation. Leaf and bark extracts showed dose-dependent cytotoxicity against PC-9, MCF-7, and MDA-MB-231 cells, while fruit extracts were weaker. In human lymphocytes, bark (Bileća) and leaf (Tuzla) extracts decreased nuclear division and induced micronuclei at 200 µg/mL. Molecular docking indicated strong bacterial target binding for loganin and cornuside, supporting the antibacterial and antitumor potential of C. mas.
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Claims 11
Claim · model-written summary
Phenolic and flavonoid content of Cornus mas varied by plant part, with location-related differences among samples.
- Taxon
- Cornus mas
Cornus mase0 - Outcome
- phenolic and flavonoid contente1
- Qualifier
- varied by plant part, with location-related differences among samplese1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Cornus mas L. is traditionally used for various medicinal purposes”
e1“phenolic and flavonoid content varied by plant part, with location-related differences among samples”
Claim · model-written summary
Phenolic and flavonoid content of Cornus mas was highest in leaf and fruit from Bijeljina.
- Taxon
- Cornus masCornus mase0
- Organ / stage
- leaf and fruite2
- Outcome
- phenolic and flavonoid contente1
- Direction
- higheste2
- Setting
- Bijeljinae2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Cornus mas L. is traditionally used for various medicinal purposes”
e1“phenolic and flavonoid content varied by plant part, with location-related differences among samples”
e2“with the highest in leaf and fruit from Bijeljina”
Claim · model-written summary
Phenolic and flavonoid content of Cornus mas leaf was lowest in samples from Sarajevo.
- Taxon
- Cornus masCornus mase0
- Organ / stage
- leafe3
- Outcome
- phenolic and flavonoid contente1
- Direction
- loweste3
- Setting
- Sarajevoe3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Cornus mas L. is traditionally used for various medicinal purposes”
e1“phenolic and flavonoid content varied by plant part, with location-related differences among samples”
e3“the lowest in leaf from Sarajevo”
Claim · model-written summary
Antioxidant activity of Cornus mas was much better in leaf and bark than in fruit.
- Taxon
- Cornus masCornus mase0
- Organ / stage
- leaf and barke4
- Outcome
- Antioxidant activitye4
- Direction
- bettere4
- Comparator
- fruite4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Cornus mas L. is traditionally used for various medicinal purposes”
e4“Antioxidant activity was much better in leaf and bark than in fruit”
Claim · model-written summary
Cornus mas extracts inhibited ESBL-producing Escherichia coli, with MICs mainly at 125 µg/mL.
- Taxon
- Cornus masCornus mase0
- Interactor
- ESBL-producing Escherichia coli
.jpg?width=60)
Escherichia colie5pathogen - Outcome
- MICse5
- Direction
- inhibitede5
- Value
- 125 µg/mLe5
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
.jpg?width=500)
Verbatim
e0“Cornus mas L. is traditionally used for various medicinal purposes”
e5“Extracts inhibited ESBL-producing Escherichia coli, with MICs mainly at 125 µg/mL”
Claim · model-written summary
Bark extract of Cornus mas from Tuzla reduced biofilm formation at 250 µg/mL.
- Taxon
- Cornus masCornus mase0
- Organ / stage
- barke6
- Outcome
- biofilm formatione6
- Direction
- reducede6
- Value
- 250 µg/mLe6
- Setting
- Tuzlae6
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Cornus mas L. is traditionally used for various medicinal purposes”
e6“bark extract (Tuzla) showed 250 µg/mL and reduced biofilm formation”
Claim · model-written summary
Leaf and bark extracts of Cornus mas showed dose-dependent cytotoxicity against PC-9, MCF-7 and MDA-MB-231 cells.
- Taxon
- Cornus masCornus mase0
- Organ / stage
- Leaf and barke7
- Outcome
- cytotoxicitye7
- Qualifier
- dose-dependente7
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Cornus mas L. is traditionally used for various medicinal purposes”
e7“Leaf and bark extracts showed dose-dependent cytotoxicity against PC-9, MCF-7, and MDA-MB-231 cells, while fruit extracts were weaker”
Claim · model-written summary
Fruit extracts of Cornus mas were weaker in cytotoxicity than leaf and bark extracts.
- Taxon
- Cornus masCornus mase0
- Organ / stage
- fruit extractse7
- Outcome
- cytotoxicitye7
- Direction
- weakere7
- Comparator
- Leaf and bark extractse7
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Cornus mas L. is traditionally used for various medicinal purposes”
e7“Leaf and bark extracts showed dose-dependent cytotoxicity against PC-9, MCF-7, and MDA-MB-231 cells, while fruit extracts were weaker”
Claim · model-written summary
Bark (Bileća) and leaf (Tuzla) extracts of Cornus mas decreased nuclear division in human lymphocytes at 200 µg/mL.
- Taxon
- Cornus masCornus mase0
- Treatment
- bark (Bileća) and leaf (Tuzla) extractse1
- Outcome
- nuclear divisione1
- Direction
- decreasede1
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Cornus mas L. is traditionally used for various medicinal purposes”
e1“In human lymphocytes, bark (Bileća) and leaf (Tuzla) extracts decreased nuclear division and induced micronuclei at 200 µg/mL”
Claim · model-written summary
Bark (Bileća) and leaf (Tuzla) extracts of Cornus mas induced micronuclei in human lymphocytes at 200 µg/mL.
- Taxon
- Cornus masCornus mase0
- Treatment
- bark (Bileća) and leaf (Tuzla) extractse1
- Outcome
- micronucleie1
- Direction
- inducede1
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Cornus mas L. is traditionally used for various medicinal purposes”
e1“In human lymphocytes, bark (Bileća) and leaf (Tuzla) extracts decreased nuclear division and induced micronuclei at 200 µg/mL”
Claim · model-written summary
Molecular docking indicated strong bacterial target binding for loganin and cornuside from Cornus mas.
- Taxon
- Cornus masCornus mase0
- Compound
- loganin and cornusidee2
- Outcome
- bacterial target bindinge2
- Qualifier
- Molecular dockinge2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Cornus mas L. is traditionally used for various medicinal purposes”
e2“Molecular docking indicated strong bacterial target binding for loganin and cornuside”