Retroviridae 23 claims

Claim · model-written summary

This is the first report of GALV in New Zealand and the first report of GALV in Dianthus worldwide.

Taxon

DianthusDianthuse2

Interactor

GALVGibbon ape leukemia viruse2pathogen

Outcome

first report of GALVe2

Setting

New Zealande2

Verbatim

t0

“First Report of Grapevine Algerian Latent Virus in Carnation in New Zealand”

e2

“To our knowledge, this is the first report of GALV in New Zealand, and the first report in the host Dianthus in the world”

Claim · model-written summary

GALV, together with CERV, was detected in all Dianthus plants tested.

Taxon

DianthusDianthuse3

Interactor

GALVGibbon ape leukemia viruse3pathogen

Second interactor

CERVCarnation etched ring viruse3pathogen

Outcome

detectede3

Not reportedDirection

Verbatim

t0

“First Report of Grapevine Algerian Latent Virus in Carnation in New Zealand”

e3

“GALV (along with CERV) was detected from all Dianthus plants while the Alstroemeria samples were negative”

Claim · model-written summary

Alstroemeria samples tested negative for GALV.

Taxon

Alstroemeria spp.Alstroemeriae4

Interactor

GALVGibbon ape leukemia viruse4pathogen

Outcome

samples were negativee3

Not reportedDirection

Verbatim

t0

“First Report of Grapevine Algerian Latent Virus in Carnation in New Zealand”

e4

“two asymptomatic Alstroemeria spp. were collected from the same address and tested individually using the GALV-specific RT-PCR”

e3

“GALV (along with CERV) was detected from all Dianthus plants while the Alstroemeria samples were negative”

Claim · model-written summary

Compounds 1 and 5 showed good activity against HIV-1 induced cytopathic effects at non-cytotoxic concentrations.

Taxon

Cyclocarya paliurusCyclocarya paliuruse0

Interactor

HIV-1Human immunodeficiency virus 1e1other

Compound

compounds 1 and 5e1

Outcome

HIV-1 induced cytopathic effectse1

Value

31.74 and 10.76 μMe2

Qualifier

therapeutic index (TI) values of >13.02 and 25.46e2

Verbatim

e0

“Eight phenolic compounds including five glucuronides were isolated from the leaves of Cyclocarya paliurus”

e1

“compounds 1 and 5 had good activities against HIV-1 induced cytopathic effects in C8166 lymphocyte at non-cytotoxic concentrations”

e2

“with EC50 values of 31.74 and 10.76 μM, and therapeutic index (TI) values of >13.02 and 25.46, respectively”

Claim · model-written summary

Crude extract of A. klaineanum root bark (AKER) inhibits HIV-1 integrase with attractive activity

Taxon

A.klaineanumAntrocaryon klaineanume3

Material

AKERe3

Organ / stage

root barke3

Interactor

HIV-1Human immunodeficiency virus 1e3pathogen

Gene

HIV-1 integrasee3

Outcome

activities on HIV-1 integrasee3

Direction

attractivee3

Value

1.96e3

Verbatim

e3

“The crude extract of A.klaineanum root bark (AKER) and AKETF1 exhibited attractive activities on HIV-1 integrase with IC 50 values of 1.96 and 24.04 μg/mL, respectively”

Claim · model-written summary

AKETF1 extract inhibits HIV-1 integrase with attractive activity

Taxon

A.klaineanumAntrocaryon klaineanume3

Material

AKETF1e3

Interactor

HIV-1Human immunodeficiency virus 1e3pathogen

Gene

HIV-1 integrasee3

Outcome

activities on HIV-1 integrasee3

Direction

attractivee3

Value

24.04 μg/mLe3

Verbatim

e3

“The crude extract of A.klaineanum root bark (AKER) and AKETF1 exhibited attractive activities on HIV-1 integrase with IC 50 values of 1.96 and 24.04 μg/mL, respectively”

Claim · model-written summary

Culm infusion extract had lower MIC50 against HIV1 reverse transcriptase activity than leaf infusion extract (844.05 µg mL-1).

Taxon

Merostachys neesiiMerostachys neesiie0

Treatment

Culm infusion extracte1

Interactor

HIV1Human immunodeficiency virus 1e2other

Outcome

MIC50e1

Direction

lowere1

Value

844.05 µg mL-1e1

Comparator

leaf infusion extracte1

Verbatim

e0

“leaves and culms from Merostachys neesii Ruprecht, an endemic Brazilian bamboo species”

e1

“Culm infusion extract showed the lower MIC50 (844.05 µg mL-1), followed by leaf infusion extract (1310.39 µg mL-1)”

e2

“Extracts and phases were also tested against the HIV1 transcriptase reverse (RT) activity”

Claim · model-written summary

Leaf infusion extract had MIC50 against HIV1 reverse transcriptase activity of 1310.39 µg mL-1.

Taxon

Merostachys neesiiMerostachys neesiie0

Treatment

leaf infusion extracte1

Interactor

HIV1Human immunodeficiency virus 1e2other

Outcome

MIC50e1

Value

1310.39 µg mL-1e1

Verbatim

e0

“leaves and culms from Merostachys neesii Ruprecht, an endemic Brazilian bamboo species”

e1

“Culm infusion extract showed the lower MIC50 (844.05 µg mL-1), followed by leaf infusion extract (1310.39 µg mL-1)”

e2

“Extracts and phases were also tested against the HIV1 transcriptase reverse (RT) activity”

Claim · model-written summary

Methanol extract of Carica papaya aerial parts showed anti-HIV-1 activity, with a therapeutic index of 5.51 relative to the standard drug.

Taxon

Carica papayaCarica papayae0

Treatment

Methanole0

Interactor

HIV-1Human immunodeficiency virus 1e0other

Outcome

activity as anti-HIV-1 agentse0

Value

5.51e0

Qualifier

Therapeutic index (TI)e0

Comparator

standard druge0

Not reportedDirection

Verbatim

e0

“Methanol and aqueous extracts of Carica papaya aerial parts showed activity as anti-HIV-1 agents, both of the extracts Therapeutic index (TI) of 5.51 and 7.13 compared with the standard drug”

Claim · model-written summary

Aqueous extract of Carica papaya aerial parts showed anti-HIV-1 activity, with a therapeutic index of 7.13 relative to the standard drug.

Taxon

Carica papayaCarica papayae0

Treatment

aqueous extractse0

Interactor

HIV-1Human immunodeficiency virus 1e0other

Outcome

activity as anti-HIV-1 agentse0

Value

7.13e0

Qualifier

Therapeutic index (TI)e0

Comparator

standard druge0

Not reportedDirection

Verbatim

e0

“Methanol and aqueous extracts of Carica papaya aerial parts showed activity as anti-HIV-1 agents, both of the extracts Therapeutic index (TI) of 5.51 and 7.13 compared with the standard drug”