By organism › Fungi › Cytosporaceae

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Compound 6i at 40 mg/L had a satisfactory in vivo protective effect against Valsa mali.

Taxon: Valsa maliCytospora malie4
Treatment: Compound 6i at 40 mg/Le4
Outcome: in vivo protective effecte4
Value: 40 mg/Le4
Qualifier: satisfactorye4

Not reportedComparatorDirection

Verbatim

e4
“Compound 6i at 40 mg/L showed a satisfactory in vivo protective effect against Valsa mali”
✓ located verbatim in the source · abstract, characters 820–909

Title

Design, Synthesis, and Evaluation of Antifungal Bioactivity of Novel Pyrazole Carboxamide Thiazole Derivatives as SDH Inhibitors

Meng Li; Weiwei Wang; Xiang Cheng; et al. Journal of Agricultural and Food Chemistry 2023. doi:10.1021/acs.jafc.3c02671

Other claims from this paper (8)

Intervention effect Most pyrazole carboxamide thiazole derivatives showed good antifungal activity against Valsa mali.
Intervention effect Compound 6i had an EC50 of 1.77 against Valsa mali, better than the control drug boscalid.
Intervention effect Compound 19i had an EC50 of 1.97 mg/L against Valsa mali, better than the control drug boscalid.
Intervention effect Compound 23i had excellent inhibitory activity against Rhizoctonia solani, with an EC50 of 3.79 mg/L.
Intervention effect Compound 6i significantly damaged the surface morphology of Valsa mali.
Association Docking indicates compound 6i interacts with succinate dehydrogenase through hydrogen bonding and sigma-pi interaction.
Association The binding mode of compound 6i is similar to that of boscalid in succinate dehydrogenase.
Mechanism An enzyme activity experiment verified the action mode of compound 6i.

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Compound 6i significantly damaged the surface morphology of Valsa mali.

Taxon: Valsa maliCytospora malie5
Treatment: compound 6ie5
Outcome: surface morphologye5
Qualifier: to interfere with the growth of Valsa malie5

Not reportedComparatorDirection

Verbatim

e5
“compound 6i could significantly damage the surface morphology to interfere with the growth of Valsa mali”
✓ located verbatim in the source · abstract, characters 964–1068

Title

Design, Synthesis, and Evaluation of Antifungal Bioactivity of Novel Pyrazole Carboxamide Thiazole Derivatives as SDH Inhibitors

Meng Li; Weiwei Wang; Xiang Cheng; et al. Journal of Agricultural and Food Chemistry 2023. doi:10.1021/acs.jafc.3c02671

Other claims from this paper (8)

Intervention effect Most pyrazole carboxamide thiazole derivatives showed good antifungal activity against Valsa mali.
Intervention effect Compound 6i had an EC50 of 1.77 against Valsa mali, better than the control drug boscalid.
Intervention effect Compound 19i had an EC50 of 1.97 mg/L against Valsa mali, better than the control drug boscalid.
Intervention effect Compound 23i had excellent inhibitory activity against Rhizoctonia solani, with an EC50 of 3.79 mg/L.
Intervention effect Compound 6i at 40 mg/L had a satisfactory in vivo protective effect against Valsa mali.
Association Docking indicates compound 6i interacts with succinate dehydrogenase through hydrogen bonding and sigma-pi interaction.
Association The binding mode of compound 6i is similar to that of boscalid in succinate dehydrogenase.
Mechanism An enzyme activity experiment verified the action mode of compound 6i.

Associationobservedoriginal resultsimulated

Claim · model-written summary

Docking indicates compound 6i interacts with succinate dehydrogenase through hydrogen bonding and sigma-pi interaction.

Taxon: Valsa maliCytospora malie1
Treatment: compound 6ie6
Gene: succinate dehydrogenase (SDH)e6
Outcome: hydrogen bonding and σ–π interactione6

Not reportedDirection

Verbatim

e1
“most compounds ( 3i, 5i, 6i, 7i, 9i, 12i, 16i, 19i, and 23i ) exhibited good antifungal activities against Valsa mali”
✓ located verbatim in the source · abstract, characters 370–487

e6
“compound 6i interacts with TRP O: 173, SER P: 39, TYR Q: 58, and ARG P: 43 of succinate dehydrogenase (SDH) through hydrogen bonding and σ–π interaction”
✓ located verbatim in the source · abstract, characters 1117–1269

Title

Design, Synthesis, and Evaluation of Antifungal Bioactivity of Novel Pyrazole Carboxamide Thiazole Derivatives as SDH Inhibitors

Meng Li; Weiwei Wang; Xiang Cheng; et al. Journal of Agricultural and Food Chemistry 2023. doi:10.1021/acs.jafc.3c02671

Other claims from this paper (8)

Intervention effect Most pyrazole carboxamide thiazole derivatives showed good antifungal activity against Valsa mali.
Intervention effect Compound 6i had an EC50 of 1.77 against Valsa mali, better than the control drug boscalid.
Intervention effect Compound 19i had an EC50 of 1.97 mg/L against Valsa mali, better than the control drug boscalid.
Intervention effect Compound 23i had excellent inhibitory activity against Rhizoctonia solani, with an EC50 of 3.79 mg/L.
Intervention effect Compound 6i at 40 mg/L had a satisfactory in vivo protective effect against Valsa mali.
Intervention effect Compound 6i significantly damaged the surface morphology of Valsa mali.
Association The binding mode of compound 6i is similar to that of boscalid in succinate dehydrogenase.
Mechanism An enzyme activity experiment verified the action mode of compound 6i.

Associationobservedoriginal resultsimulated

Claim · model-written summary

The binding mode of compound 6i is similar to that of boscalid in succinate dehydrogenase.

Taxon: Valsa maliCytospora malie1
Gene: SDHe7
Outcome: binding modee7
Direction: similare7
Comparator: boscalide7

Verbatim

e1
“most compounds ( 3i, 5i, 6i, 7i, 9i, 12i, 16i, 19i, and 23i ) exhibited good antifungal activities against Valsa mali”
✓ located verbatim in the source · abstract, characters 370–487

e7
“its binding mode is similar to that of boscalid and SDH”
✓ located verbatim in the source · abstract, characters 1275–1330

Title

Design, Synthesis, and Evaluation of Antifungal Bioactivity of Novel Pyrazole Carboxamide Thiazole Derivatives as SDH Inhibitors

Meng Li; Weiwei Wang; Xiang Cheng; et al. Journal of Agricultural and Food Chemistry 2023. doi:10.1021/acs.jafc.3c02671

Other claims from this paper (8)

Intervention effect Most pyrazole carboxamide thiazole derivatives showed good antifungal activity against Valsa mali.
Intervention effect Compound 6i had an EC50 of 1.77 against Valsa mali, better than the control drug boscalid.
Intervention effect Compound 19i had an EC50 of 1.97 mg/L against Valsa mali, better than the control drug boscalid.
Intervention effect Compound 23i had excellent inhibitory activity against Rhizoctonia solani, with an EC50 of 3.79 mg/L.
Intervention effect Compound 6i at 40 mg/L had a satisfactory in vivo protective effect against Valsa mali.
Intervention effect Compound 6i significantly damaged the surface morphology of Valsa mali.
Association Docking indicates compound 6i interacts with succinate dehydrogenase through hydrogen bonding and sigma-pi interaction.
Mechanism An enzyme activity experiment verified the action mode of compound 6i.

Mechanismobservedoriginal resultmeasured

Claim · model-written summary

An enzyme activity experiment verified the action mode of compound 6i.

Taxon: Valsa maliCytospora malie1
Outcome: action modee2
Qualifier: enzyme activity experimente2

Verbatim

e1
“most compounds ( 3i, 5i, 6i, 7i, 9i, 12i, 16i, 19i, and 23i ) exhibited good antifungal activities against Valsa mali”
✓ located verbatim in the source · abstract, characters 370–487

e2
“The enzyme activity experiment also further verified its action mode”
✓ located verbatim in the source · abstract, characters 1332–1400

Title

Design, Synthesis, and Evaluation of Antifungal Bioactivity of Novel Pyrazole Carboxamide Thiazole Derivatives as SDH Inhibitors

Meng Li; Weiwei Wang; Xiang Cheng; et al. Journal of Agricultural and Food Chemistry 2023. doi:10.1021/acs.jafc.3c02671

Other claims from this paper (8)

Intervention effect Most pyrazole carboxamide thiazole derivatives showed good antifungal activity against Valsa mali.
Intervention effect Compound 6i had an EC50 of 1.77 against Valsa mali, better than the control drug boscalid.
Intervention effect Compound 19i had an EC50 of 1.97 mg/L against Valsa mali, better than the control drug boscalid.
Intervention effect Compound 23i had excellent inhibitory activity against Rhizoctonia solani, with an EC50 of 3.79 mg/L.
Intervention effect Compound 6i at 40 mg/L had a satisfactory in vivo protective effect against Valsa mali.
Intervention effect Compound 6i significantly damaged the surface morphology of Valsa mali.
Association Docking indicates compound 6i interacts with succinate dehydrogenase through hydrogen bonding and sigma-pi interaction.
Association The binding mode of compound 6i is similar to that of boscalid in succinate dehydrogenase.

Observationobservedoriginal resultmeasured

Claim · model-written summary

Three genes (CcOah, CcOdc1 and CcOdc2) directly involved in oxalic acid biosynthesis and catabolism were identified in C. chrysosperma.

Taxon: C. chrysospermaCytospora chrysospermae0
Gene: CcOah, CcOdc1, and CcOdc2e0
Outcome: directly involved in OA biosynthesis and catabolisme0

Verbatim

e0
“we identified three genes (CcOah, CcOdc1, and CcOdc2) directly involved in OA biosynthesis and catabolism in C. chrysosperma”
✓ located verbatim in the source · abstract, characters 330–454

Title

Oxalic Acid Metabolism Contributes to Full Virulence and Pycnidial Development in the Poplar Canker Fungus Cytospora chrysosperma

Yuanyuan Wang; Yonglin Wang Phytopathology 2020. doi:10.1094/phyto-10-19-0381-r

Other claims from this paper (9)

Observation CcOah is required for oxalic acid biogenesis in C. chrysosperma.
Observation All three OA genes were highly upregulated during early infection stages of the poplar stem.
Intervention effect Deletion of any of the three genes obviously reduced pycnidial production.
Intervention effect Deletion of any of the three genes caused no abnormality of hyphal growth and morphology.
Intervention effect Each individual deletion strain produced significantly smaller lesions on poplar twigs and leaves.
Intervention effect Exogenous application of oxalic acid or citric acid complemented the virulence defects of the DeltaCcOah and DeltaCcOdc1 strains.
Intervention effect The DeltaCcOah strain strongly promoted the reactive oxygen species burst of poplar leaves during infection.
Observation Induced secretion of oxalic acid was observed after poplar stem extracts were added to C. chrysosperma cultures.
Mechanism The results indicate that oxalic acid acts as an important virulence factor of C. chrysosperma.

Observationobservedoriginal resultmeasured

Claim · model-written summary

CcOah is required for oxalic acid biogenesis in C. chrysosperma.

Taxon: Cytospora chrysospermaCytospora chrysospermat0
Gene: CcOahe0
Outcome: OA biogenesise0

Verbatim

e0
“We demonstrated that CcOah is required for OA biogenesis”
✓ located verbatim in the source · abstract, characters 456–512

t0
“Cytospora chrysosperma”
✓ located verbatim in the source · title, characters 107–129

Title

Oxalic Acid Metabolism Contributes to Full Virulence and Pycnidial Development in the Poplar Canker Fungus Cytospora chrysosperma

Yuanyuan Wang; Yonglin Wang Phytopathology 2020. doi:10.1094/phyto-10-19-0381-r

Other claims from this paper (9)

Observationobservedoriginal resultmeasured

Claim · model-written summary

All three OA genes were highly upregulated during early infection stages of the poplar stem.

Taxon: Cytospora chrysospermaCytospora chrysospermat0
Organ / stage: poplar steme0
Gene: All three genese0
Outcome: highly upregulated during early infection stagese0
Direction: upregulatede0

Verbatim

e0
“All three genes were found to be highly upregulated during early infection stages of the poplar stem”
✓ located verbatim in the source · abstract, characters 514–614

t0
“Cytospora chrysosperma”
✓ located verbatim in the source · title, characters 107–129

Title

Oxalic Acid Metabolism Contributes to Full Virulence and Pycnidial Development in the Poplar Canker Fungus Cytospora chrysosperma

Yuanyuan Wang; Yonglin Wang Phytopathology 2020. doi:10.1094/phyto-10-19-0381-r

Other claims from this paper (9)

Intervention effectobservedoriginal resultmeasured

Claim · model-written summary

Deletion of any of the three genes obviously reduced pycnidial production.

Taxon: Cytospora chrysospermaCytospora chrysospermat0
Treatment: deletion of any of the three genese0
Outcome: pycnidial productione0
Direction: reductione0

Not reportedComparator

Verbatim

e0
“The deletion of any of the three genes led to an obvious reduction of pycnidial production but no abnormality of hyphal growth and morphology”
✓ located verbatim in the source · abstract, characters 616–757

t0
“Cytospora chrysosperma”
✓ located verbatim in the source · title, characters 107–129

Title

Oxalic Acid Metabolism Contributes to Full Virulence and Pycnidial Development in the Poplar Canker Fungus Cytospora chrysosperma

Yuanyuan Wang; Yonglin Wang Phytopathology 2020. doi:10.1094/phyto-10-19-0381-r

Other claims from this paper (9)

Intervention effectobservedoriginal resultno effectmeasured

Claim · model-written summary

Deletion of any of the three genes caused no abnormality of hyphal growth and morphology.

Taxon: Cytospora chrysospermaCytospora chrysospermat0
Treatment: deletion of any of the three genese0
Outcome: hyphal growth and morphologye0
Direction: no abnormalitye0

Not reportedComparator

Verbatim

e0
“The deletion of any of the three genes led to an obvious reduction of pycnidial production but no abnormality of hyphal growth and morphology”
✓ located verbatim in the source · abstract, characters 616–757

t0
“Cytospora chrysosperma”
✓ located verbatim in the source · title, characters 107–129

Title

Oxalic Acid Metabolism Contributes to Full Virulence and Pycnidial Development in the Poplar Canker Fungus Cytospora chrysosperma

Yuanyuan Wang; Yonglin Wang Phytopathology 2020. doi:10.1094/phyto-10-19-0381-r

Other claims from this paper (9)

Cytosporaceae 40 claims

40 claims