Intervention effectmodel-written summary

CRISPR/Cas9 editing of ZmRACK1 in maize increased susceptibility to MCMV.

A claim from The ZmRACK1–ZmCDPK7–ZmAPX1 module regulates plant antiviral immunity · 2026

Intervention effectobservedoriginal resultnegativemeasured

Claim · model-written summary

CRISPR/Cas9 editing of ZmRACK1 in maize increased susceptibility to MCMV.

Taxon
maizeZea mayse5
Treatment
CRISPR/Cas9-mediated genome editing of ZmRACK1e5
Interactor
MCMVMaize chlorotic mottle viruse5pathogen
Gene
ZmRACK1e5
Outcome
susceptibility to MCMVe5
Direction
increasede5

Not reportedMaterialCompoundOrgan / stageSecond interactorSecond interactor roleComparatorSettingValueQualifier

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Zea mays
Zea mays · TaxonAkwugo · CC BY-SA 4.0 · Wikimedia Commons ↗

Verbatim

e5

“CRISPR/Cas9-mediated genome editing of ZmRACK1 in maize resulted in increased susceptibility to MCMV”

✓ located verbatim in the source · abstract, characters 1112–1212

Title

The ZmRACK1–ZmCDPK7–ZmAPX1 module regulates plant antiviral immunity

Yuyang Zhang; Niannian Li; Qiongqiong Wang; et al. Journal of Integrative Plant Biology 2026. doi:10.1111/jipb.70285

Other claims from this paper (9)

Record rev-caac1388eb593b2aa123bc371d0f965b381ae4832d7c4dd3f9c792e675c0995b · schema claims-v0.9 · position 8 in the model’s answer

loss of function · Maize chlorotic mottle virus · Zea mays (maize)Results agree

5 papers: 0 positive, 5 negative or no effect

4 papers in the same direction as this claim

  1. negative
    ZmCAT silencing facilitated MCMV RNA accumulation.

    A novel pathogenicity determinant hijacks maize catalase 1 to enhance viral multiplication and infection · 2021

    Same directionCited by this paper

  2. negative
    Silencing ZmELC increased Maize chlorotic mottle virus accumulation.

    Maize Elongin C interacts with the viral genome‐linked protein, VPg, of Sugarcane mosaic virus and facilitates virus infection · 2014

    Same direction

  3. negative
    Silencing of ZmMTC, ZmSCI1 or ZmTIP1 significantly promoted MCMV infection in maize.

    N6-Methyladenosine RNA Modification Regulates Maize Resistance to Maize Chlorotic Mottle Virus Infection · 2024

    Same direction

  4. negative
    Silencing ZmGOX1 facilitated MCMV infection.

    Proteome and Ubiquitinome Analyses Reveal the Involvement of Ubiquitination in Resistance to Maize Lethal Necrosis · 2025

    Same direction

See all 5 papers →

Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.

Functional evidence on ZmRACK1

Claims that state a gain or loss of function of this gene and what it did to a trait, compared with wild type or a control.

ZmRACK1 · Open in the knowledge graph

Zea mays (maize)2 papers · 1 trait

Disease resistance2 papersSame role (checked)

2 promotes
  1. Promotes
    ZmRACK1 overexpression reduced Exserohilum turcicum symptoms on maize leaves.

    Maize ZmRACK1 Is Involved in the Plant Response to Fungal Phytopathogens · 2014

    gain of function → more of the trait

  2. Promotes
    CRISPR/Cas9 editing of ZmRACK1 in maize increased susceptibility to MCMV.

    The ZmRACK1–ZmCDPK7–ZmAPX1 module regulates plant antiviral immunity · 2026

    loss of function → less of the traitThis claim

Checked pairs of papers

The program reads each claim's manipulation and the direction of the trait, and from them the gene's role (gain and more, or loss and less, means it promotes the trait). Roles are read by program from each claim's wording. Pairs of papers on the same host, gene and trait were checked claim by claim by two model readers; a pair is marked checked only when both accept it. Gene layer v0.8, 21 trait classes.