Intervention effectmodel-written summary

MYB15 mutation increased susceptibility to Pseudomonas pathogens.

A claim from Coordination of microbe–host homeostasis by crosstalk with plant innate immunity · 2021

Intervention effectobservedoriginal resultnegativemeasured

Claim · model-written summary

Taxon: Arabidopsis thalianaArabidopsis thalianat0
Treatment: mutation of one commensal-downregulated transcription factor, MYB15e0
Interactor: Pseudomonas pathogense0pathogen
Gene: MYB15e0
Outcome: susceptible to opportunistic Pseudomonas pathogense0
Direction: moree0

Not reportedMaterialCompoundOrgan / stageSecond interactorSecond interactor roleComparatorSettingValueQualifier

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

*Arabidopsis thaliana* · TaxonOriginal uploader was Brona at en.wikipedia . User:Roepers at nl.wikipedia · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

e0
“mutation of one commensal-downregulated transcription factor, MYB15, renders the plants more susceptible to opportunistic Pseudomonas pathogens”
✓ located verbatim in the source · abstract, characters 1195–1338

t0
“Arabidopsis thaliana root growth inhibition”
✓ located verbatim in the source · abstract, characters 464–507

Title

Coordination of microbe–host homeostasis by crosstalk with plant innate immunity

Ka-Wai Ma; Yulong Niu; Yong Jia; et al. Nature Plants 2021. doi:10.1038/s41477-021-00920-2

Other claims from this paper (6)

Intervention effect Forty-one percent of tested root commensals suppressed immune-triggered root growth inhibition.
Intervention effect Immune activation altered communities of RGI-non-suppressive strains.
Intervention effect RGI-suppressive strains attenuated the effect of immune activation on community profiles.
Intervention effect SynCom colonization altered expression of 174 core host genes.
Intervention effect RGI-suppressive SynComs downregulated immune-related genes.
Intervention effect Precolonization with RGI-suppressive SynComs increased susceptibility to Pseudomonas pathogens.

Record rev-cbbd83efa26092c547eb568464eecde757b94a7a7101b7b93caae0213f96ed45 · schema claims-v0.9 · position 7 in the model’s answer

loss of function · disease · Arabidopsis thaliana (thale cress)Positive and negative results

82 papers: 31 positive, 51 negative or no effect

50 papers in the same direction as this claim · 31 in the opposite direction

positive
Mutations in toxA, plcS and gacA significantly reduced UCBPP-PA14 pathogenicity in both Arabidopsis and mouse hosts.
Common Virulence Factors for Bacterial Pathogenicity in Plants and Animals · 1995
Opposite direction
positive
hkt1 mutations abolished the growth inhibition of sos3-1 caused by K(+) deficiency in low-Ca(2+) medium.
AtHKT1 is a salt tolerance determinant that controls Na ⁺ entry into plant roots · 2001
Opposite direction
positive
PHF1 mutation increased arsenate resistance.
PHOSPHATE TRANSPORTER TRAFFIC FACILITATOR1 Is a Plant-Specific SEC12-Related Protein That Enables the Endoplasmic Reticulum Exit of a High-Affinity Phosphate Transporter in Arabidopsis [W] · 2005
Opposite direction
positive
A CTR2 mutation increased yeast resistance to toxic copper.
Molecular Characterization of a Putative Arabidopsis thaliana Copper Transporter and Its Yeast Homologue · 1995
Opposite direction
positive
SAMDC1 loss of function reduced BSCTV susceptibility.
BSCTV C2 Attenuates the Degradation of SAMDC1 to Suppress DNA Methylation-Mediated Gene Silencing in Arabidopsis · 2011
Opposite direction
positive
AtNIP7;1 loss of function increased Arabidopsis tolerance to AsIII.
The Arabidopsis thaliana aquaglyceroporin AtNIP7;1 is a pathway for arsenite uptake · 2008
Opposite direction
positive
Disruption of aldA and aldB reduced virulence on A. thaliana.
Indole-3-acetaldehyde dehydrogenase-dependent auxin synthesis contributes to virulence of Pseudomonas syringae strain DC3000 · 2018
Opposite direction
positive
Arabidopsis thaliana RNA interference-PARP lines were more resistant to abiotic stress.
Silencing of poly(ADP-ribose) polymerase in plants alters abiotic stress signal transduction · 2007
Opposite direction

73 papers more in this group

See all 82 papers →

Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.

Functional evidence on MYB15

Claims that state a gain or loss of function of this gene and what it did to a trait, compared with wild type or a control.

MYB15 · NCBI Gene 821904 ↗ · Open in the knowledge graph

Arabidopsis thaliana (thale cress)2 papers · 1 trait

Disease resistance2 papers

2 promotes

Promotes
Constitutive expression of MYB15 increases lignin content independently of immune activation.
SG2-Type R2R3-MYB Transcription Factor MYB15 Controls Defense-Induced Lignification and Basal Immunity in Arabidopsis · 2017
gain of function → more of the trait
Promotes
MYB15 mutation increased susceptibility to Pseudomonas pathogens.
Coordination of microbe–host homeostasis by crosstalk with plant innate immunity · 2021
loss of function → less of the traitThis claim

The program reads each claim's manipulation and the direction of the trait, and from them the gene's role (gain and more, or loss and less, means it promotes the trait). Roles are read by program from each claim's wording. Pairs of papers on the same host, gene and trait were checked claim by claim by two model readers; a pair is marked checked only when both accept it. Gene layer v0.8, 21 trait classes.

Other papers on the same question

loss of function · disease · Arabidopsis thaliana (thale cress)Positive and negative results

Functional evidence on MYB15

Arabidopsis thaliana (thale cress)2 papers · 1 trait

Disease resistance2 papers